Strain-dependent effects of D2 dopaminergic and muscarinic-cholinergic agonists and antagonists on memory consolidation processes in mice

Antonella Gasbarri, Antonio Sulli, Claudio Pacitti, Stefano Puglisi-Allegra, Simona Cabib, Claudio Castellano, Ines Introini-Collison, James L. McGaugh

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The interaction between muscarinic-cholinergic and dopaminergic systems in the modulation of memory storage of Y-maze discrimination (YMD) task was examined in C57BL/6 and DBA/2 strains of mice. In C57BL/6 mice, post-training systemic (i.p.) administration of the D2-agonist quinpirole facilitated retention and the D2-antagonist (-)-sulpiride impaired retention. Opposite effects were observed in DBA/2 strain. The facilitating or impairing effects of quinpirole and (-)-sulpiride were blocked by simultaneous post-training administration of muscarinic-cholinergic agonists and antagonists. The memory enhancing effects of the cholinergic agonist oxotremorine were not blocked by simultaneous administration of sulpiride in C57BL/6 mice or quinpirole in DBA/2 mice. Furthermore, the memory impairing effects of the cholinergic antagonist atropine were not blocked by simultaneous administration of quinpirole in C57BL/6 mice or sulpiride in DBA/2 mice. These findings indicate that the effects of D2-receptor agonists and antagonists on retention of YMD task are strain-dependent and mediated through muscarinic-cholinergic mechanisms.

Original languageEnglish
Pages (from-to)97-104
Number of pages8
JournalBehavioural Brain Research
Volume86
Issue number1
DOIs
Publication statusPublished - Jun 1997

Fingerprint

Quinpirole
Muscarinic Agonists
Sulpiride
Muscarinic Antagonists
Cholinergic Antagonists
Cholinergic Agents
Inbred C57BL Mouse
Inbred DBA Mouse
Oxotremorine
Cholinergic Agonists
Atropine
Memory Consolidation
Retention (Psychology)
Discrimination (Psychology)

Keywords

  • (-)-sulpiride
  • Atropine
  • Memory
  • Oxotremorine
  • Quinpirole
  • Y-maze discrimination

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Strain-dependent effects of D2 dopaminergic and muscarinic-cholinergic agonists and antagonists on memory consolidation processes in mice. / Gasbarri, Antonella; Sulli, Antonio; Pacitti, Claudio; Puglisi-Allegra, Stefano; Cabib, Simona; Castellano, Claudio; Introini-Collison, Ines; McGaugh, James L.

In: Behavioural Brain Research, Vol. 86, No. 1, 06.1997, p. 97-104.

Research output: Contribution to journalArticle

Gasbarri, Antonella ; Sulli, Antonio ; Pacitti, Claudio ; Puglisi-Allegra, Stefano ; Cabib, Simona ; Castellano, Claudio ; Introini-Collison, Ines ; McGaugh, James L. / Strain-dependent effects of D2 dopaminergic and muscarinic-cholinergic agonists and antagonists on memory consolidation processes in mice. In: Behavioural Brain Research. 1997 ; Vol. 86, No. 1. pp. 97-104.
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