Strain-dependent effects of post-training dopamine receptor agonists and antagonists on memory storage in mice

Vincenzo Cestari, Claudio Castellano, Simona Cabib, Stefano Puglisi-Allegra

Research output: Contribution to journalArticle

Abstract

Post-training administration of the selective D1 or D2 agonists SKF 38393 and LY 171555 dose dependently impairs retention of an inhibitory avoidance response in DBA/2 mice. In agreement, the selective D1 or D2 antagonists SCH 23390 and (-)-sulpiride improve retention. These effects are opposite to those observed in the C57BL/6 strain, as previously reported. Moreover, B6D2F1 hybrids present a response to SKF 38393, LY 171555, SCH 23390, and (-)-sulpiride that parallels that of the C57BL/6 strain, thus suggesting that the neural mechanisms underlying the effects of DA agonists or antagonists on memory processes may be inherited through a dominant mode of inheritance.

Original languageEnglish
Pages (from-to)58-63
Number of pages6
JournalBehavioral and Neural Biology
Volume58
Issue number1
DOIs
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Physiology

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