Strain-dependent involvement of D1 and D2 dopamine receptors in muscarinic cholinergic influences on memory storage

Claudio Castellano, Simona Cabib, Stefano Puglisi-Allegra, Antonella Gasbarri, Antonio Sulli, Claudio Pacitti, Ines B. Introini-Collison, James L. McGaugh

Research output: Contribution to journalArticle

Abstract

These experiments examined the interaction of muscarinic and dopaminergic systems in influencing memory for one-trial inhibitory avoidance training in mice of the C57BL/6 and DBA/2 strains. In both strains, immediate post-training systemic administration of the muscarinic cholinergic agonist oxotremorine enhanced retention and the cholinergic antagonist atropine impaired retention. No effects were seen with injections 2 h post-training. Furthermore, the drugs did not affect retention performance of animals that received no footshock on the training trial. These results confirm previous findings indicating that muscarinic cholinergic drugs affect memory by influencing memory consolidation. In C57 mice, pretreatment with selective D1 or D2 dopamine (DA) receptor agonists (SKF 38393 or LY 171555, respectively) in otherwise non-effective doses (5 and 0.25 mg/kg, respectively) potentiated the effects of oxotremorine (0.04 mg/kg). Furthermore, in C57 mice pretreatment with selective D1 or D2 receptor antagonists (SCH 23390 or (-)- sulpiride) in otherwise non-effective doses (0.025 and 6 mg/kg, respectively) blocked the memory enhancing effects of oxotremorine. The memory impairing effects of atropine (3 mg/kg) were blocked by the D1 and D2 selective agonists and potentiated by the selective D1 or D2 antagonists. In contrast, in DBA mice, the D1 and D2 selective agonists antagonised the memory enhancing effects of oxotremorine (0.02 mg/kg) and potentiated the effects of atropine (2 mg/kg). Furthermore, the D1 and D2 antagonists potentiated the effects of oxotremorine and antagonised those of atropine. These findings indicate that although muscarinic cholinergic influences on memory storage are comparable in mice of these two strains, the cholinergic-dopaminergic interactions are opposite in the two strains. These results have implications for hypotheses of cholinergic and dopaminergic regulation of memory storage.

Original languageEnglish
Pages (from-to)17-26
Number of pages10
JournalBehavioural Brain Research
Volume98
Issue number1
DOIs
Publication statusPublished - Dec 1 1998

Fingerprint

Dopamine D1 Receptors
Dopamine D2 Receptors
Oxotremorine
Cholinergic Agents
Atropine
Inbred DBA Mouse
4,4a,5,6,7,8,8a,9-octahydro-5-propyl-1H-pyrzolo(3,4-g)quinoline
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
Muscarinic Agonists
Sulpiride
Dopamine Agonists
Cholinergic Antagonists
Inbred C57BL Mouse
Injections
Pharmaceutical Preparations

Keywords

  • (-)Sulpiride
  • Atropine
  • Dopamine receptors
  • Inbred mice
  • LY 171555
  • Memory
  • Muscarinic receptors
  • Oxotremorine
  • SCH 23390
  • SKF 38393

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Strain-dependent involvement of D1 and D2 dopamine receptors in muscarinic cholinergic influences on memory storage. / Castellano, Claudio; Cabib, Simona; Puglisi-Allegra, Stefano; Gasbarri, Antonella; Sulli, Antonio; Pacitti, Claudio; Introini-Collison, Ines B.; McGaugh, James L.

In: Behavioural Brain Research, Vol. 98, No. 1, 01.12.1998, p. 17-26.

Research output: Contribution to journalArticle

Castellano, Claudio ; Cabib, Simona ; Puglisi-Allegra, Stefano ; Gasbarri, Antonella ; Sulli, Antonio ; Pacitti, Claudio ; Introini-Collison, Ines B. ; McGaugh, James L. / Strain-dependent involvement of D1 and D2 dopamine receptors in muscarinic cholinergic influences on memory storage. In: Behavioural Brain Research. 1998 ; Vol. 98, No. 1. pp. 17-26.
@article{c614452c02864b149b2aa1e808469239,
title = "Strain-dependent involvement of D1 and D2 dopamine receptors in muscarinic cholinergic influences on memory storage",
abstract = "These experiments examined the interaction of muscarinic and dopaminergic systems in influencing memory for one-trial inhibitory avoidance training in mice of the C57BL/6 and DBA/2 strains. In both strains, immediate post-training systemic administration of the muscarinic cholinergic agonist oxotremorine enhanced retention and the cholinergic antagonist atropine impaired retention. No effects were seen with injections 2 h post-training. Furthermore, the drugs did not affect retention performance of animals that received no footshock on the training trial. These results confirm previous findings indicating that muscarinic cholinergic drugs affect memory by influencing memory consolidation. In C57 mice, pretreatment with selective D1 or D2 dopamine (DA) receptor agonists (SKF 38393 or LY 171555, respectively) in otherwise non-effective doses (5 and 0.25 mg/kg, respectively) potentiated the effects of oxotremorine (0.04 mg/kg). Furthermore, in C57 mice pretreatment with selective D1 or D2 receptor antagonists (SCH 23390 or (-)- sulpiride) in otherwise non-effective doses (0.025 and 6 mg/kg, respectively) blocked the memory enhancing effects of oxotremorine. The memory impairing effects of atropine (3 mg/kg) were blocked by the D1 and D2 selective agonists and potentiated by the selective D1 or D2 antagonists. In contrast, in DBA mice, the D1 and D2 selective agonists antagonised the memory enhancing effects of oxotremorine (0.02 mg/kg) and potentiated the effects of atropine (2 mg/kg). Furthermore, the D1 and D2 antagonists potentiated the effects of oxotremorine and antagonised those of atropine. These findings indicate that although muscarinic cholinergic influences on memory storage are comparable in mice of these two strains, the cholinergic-dopaminergic interactions are opposite in the two strains. These results have implications for hypotheses of cholinergic and dopaminergic regulation of memory storage.",
keywords = "(-)Sulpiride, Atropine, Dopamine receptors, Inbred mice, LY 171555, Memory, Muscarinic receptors, Oxotremorine, SCH 23390, SKF 38393",
author = "Claudio Castellano and Simona Cabib and Stefano Puglisi-Allegra and Antonella Gasbarri and Antonio Sulli and Claudio Pacitti and Introini-Collison, {Ines B.} and McGaugh, {James L.}",
year = "1998",
month = "12",
day = "1",
doi = "10.1016/S0166-4328(98)00046-1",
language = "English",
volume = "98",
pages = "17--26",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Strain-dependent involvement of D1 and D2 dopamine receptors in muscarinic cholinergic influences on memory storage

AU - Castellano, Claudio

AU - Cabib, Simona

AU - Puglisi-Allegra, Stefano

AU - Gasbarri, Antonella

AU - Sulli, Antonio

AU - Pacitti, Claudio

AU - Introini-Collison, Ines B.

AU - McGaugh, James L.

PY - 1998/12/1

Y1 - 1998/12/1

N2 - These experiments examined the interaction of muscarinic and dopaminergic systems in influencing memory for one-trial inhibitory avoidance training in mice of the C57BL/6 and DBA/2 strains. In both strains, immediate post-training systemic administration of the muscarinic cholinergic agonist oxotremorine enhanced retention and the cholinergic antagonist atropine impaired retention. No effects were seen with injections 2 h post-training. Furthermore, the drugs did not affect retention performance of animals that received no footshock on the training trial. These results confirm previous findings indicating that muscarinic cholinergic drugs affect memory by influencing memory consolidation. In C57 mice, pretreatment with selective D1 or D2 dopamine (DA) receptor agonists (SKF 38393 or LY 171555, respectively) in otherwise non-effective doses (5 and 0.25 mg/kg, respectively) potentiated the effects of oxotremorine (0.04 mg/kg). Furthermore, in C57 mice pretreatment with selective D1 or D2 receptor antagonists (SCH 23390 or (-)- sulpiride) in otherwise non-effective doses (0.025 and 6 mg/kg, respectively) blocked the memory enhancing effects of oxotremorine. The memory impairing effects of atropine (3 mg/kg) were blocked by the D1 and D2 selective agonists and potentiated by the selective D1 or D2 antagonists. In contrast, in DBA mice, the D1 and D2 selective agonists antagonised the memory enhancing effects of oxotremorine (0.02 mg/kg) and potentiated the effects of atropine (2 mg/kg). Furthermore, the D1 and D2 antagonists potentiated the effects of oxotremorine and antagonised those of atropine. These findings indicate that although muscarinic cholinergic influences on memory storage are comparable in mice of these two strains, the cholinergic-dopaminergic interactions are opposite in the two strains. These results have implications for hypotheses of cholinergic and dopaminergic regulation of memory storage.

AB - These experiments examined the interaction of muscarinic and dopaminergic systems in influencing memory for one-trial inhibitory avoidance training in mice of the C57BL/6 and DBA/2 strains. In both strains, immediate post-training systemic administration of the muscarinic cholinergic agonist oxotremorine enhanced retention and the cholinergic antagonist atropine impaired retention. No effects were seen with injections 2 h post-training. Furthermore, the drugs did not affect retention performance of animals that received no footshock on the training trial. These results confirm previous findings indicating that muscarinic cholinergic drugs affect memory by influencing memory consolidation. In C57 mice, pretreatment with selective D1 or D2 dopamine (DA) receptor agonists (SKF 38393 or LY 171555, respectively) in otherwise non-effective doses (5 and 0.25 mg/kg, respectively) potentiated the effects of oxotremorine (0.04 mg/kg). Furthermore, in C57 mice pretreatment with selective D1 or D2 receptor antagonists (SCH 23390 or (-)- sulpiride) in otherwise non-effective doses (0.025 and 6 mg/kg, respectively) blocked the memory enhancing effects of oxotremorine. The memory impairing effects of atropine (3 mg/kg) were blocked by the D1 and D2 selective agonists and potentiated by the selective D1 or D2 antagonists. In contrast, in DBA mice, the D1 and D2 selective agonists antagonised the memory enhancing effects of oxotremorine (0.02 mg/kg) and potentiated the effects of atropine (2 mg/kg). Furthermore, the D1 and D2 antagonists potentiated the effects of oxotremorine and antagonised those of atropine. These findings indicate that although muscarinic cholinergic influences on memory storage are comparable in mice of these two strains, the cholinergic-dopaminergic interactions are opposite in the two strains. These results have implications for hypotheses of cholinergic and dopaminergic regulation of memory storage.

KW - (-)Sulpiride

KW - Atropine

KW - Dopamine receptors

KW - Inbred mice

KW - LY 171555

KW - Memory

KW - Muscarinic receptors

KW - Oxotremorine

KW - SCH 23390

KW - SKF 38393

UR - http://www.scopus.com/inward/record.url?scp=0344404175&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0344404175&partnerID=8YFLogxK

U2 - 10.1016/S0166-4328(98)00046-1

DO - 10.1016/S0166-4328(98)00046-1

M3 - Article

C2 - 10210518

AN - SCOPUS:0344404175

VL - 98

SP - 17

EP - 26

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

IS - 1

ER -