Strain-dependent variations in the number of forebrain cholinergic neurons

Alberto Albanese, Stefano Gozzo, Carmela Iacopino, Maria Concetta Altavista

Research output: Contribution to journalArticlepeer-review


The morphological organization of putatively cholinergic neurons was studied in the forebrain of two inbred mouse strains (C57BL/6 and DBA/2) by means of acetylcholinesterase pharmacohistochemistry. In both strains, putatively cholinergic perikarya were seen in the caudato-putamen, medial septum, diagonal band, and basal nucleus of Meynert: in all these regions, their distribution was similar in both strains, but their density was significantly higher (from 20 to 32%) in DBA/2 mice. The present data demonstrate the existence of genetically determined differences in the organization of forebrain cholinergic systems.

Original languageEnglish
Pages (from-to)380-384
Number of pages5
JournalBrain Research
Issue number2
Publication statusPublished - May 20 1985


  • acetylcholinesterase
  • basal ganglia
  • basal nucleus of Meynert
  • cholinergic systems
  • forebrain
  • genetic study
  • morphology
  • septal nuclei

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)


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