The hyperthermic response to injected imipramine in reserpinized rats was compared in different strains of rats, such as Sprague-Dawley, Holtzman, Wistar and Long-Evans. Long-Evans rats are less reactive than all the other strains to the antireserpine activity of imipramine and show high levels of imipramine and low concentrations of desipramine (DMI) into the brain. In vitro experiments show that hepatic microsomal enzymes from Long-Evans rats metabolize imipramine to desipramine and also other substrates such as p.nitroanisol, aniline and aminopyrine to respective metabolites to a smaller extent than other rats. The reduced metabolic activity in addition to other possible reported effects, may be responsible for the reduced hyperthermic activity following imipramine in Long-Evans reserpinized rats.
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