Strain of ascending aorta on cardiac magnetic resonance in 1027 patients: Relation with age, gender, and cardiovascular disease

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Abstract

Objectives To evaluate ascending aortic strain (AAS) with cardiac magnetic resonance (CMR) in a large consecutive series of patients with different types of cardiovascular disease (CVD). Methods Two-dimensional phase-contrast gradient-echo sequences of the ascending aorta were retrospectively reviewed in 1027 patients (726 males, 301 females). Aortic lumen area was segmented using a semi-automatic approach to calculate AAS values. Subgroup analysis was performed for patients with normal CMR, tetralogy of Fallot (ToF), and ischemic heart disease (IHD). Multivariate and post-hoc analyses were performed to evaluate the effect of age, gender, and CVD on AAS values. Shapiro-Wilk, three- and two-way ANOVA, Mann-Whitney U, and Spearman correlation statistics were used. Results Multivariate analysis showed significant differences in AAS among decades of age (p < 0.001), genders (p = 0.006) and CVD subgroups (p < 0.001) without interaction among these factors. A gender-related difference (higher AAS in females) was significant in ToF (p = 0.008), while an AAS reduction during aging was observed in all CVD subgroups. Post-hoc analysis showed a significantly lower AAS in ToF and IHD patients compared to subjects with normal CMR (p < 0.001). Conclusion Differences in age, gender, and CVD independently affect AAS. The lower AAS observed in ToF fosters its assessment during follow-up in adulthood. Future studies on causes and clinical implications of a higher AAS in females affected by ToF are warranted.

Original languageEnglish
Pages (from-to)34-39
Number of pages6
JournalEuropean Journal of Radiology
Volume99
DOIs
Publication statusPublished - Feb 1 2018

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Tetralogy of Fallot
Aorta
Cardiovascular Diseases
Magnetic Resonance Spectroscopy
Myocardial Ischemia
Analysis of Variance
Multivariate Analysis

Keywords

  • Aging
  • Ascending aorta
  • Ischemic heart disease
  • Magnetic resonance imaging
  • Tetralogy of Fallot

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

@article{a57160a7490b464b9d44f138c22baa82,
title = "Strain of ascending aorta on cardiac magnetic resonance in 1027 patients: Relation with age, gender, and cardiovascular disease",
abstract = "Objectives To evaluate ascending aortic strain (AAS) with cardiac magnetic resonance (CMR) in a large consecutive series of patients with different types of cardiovascular disease (CVD). Methods Two-dimensional phase-contrast gradient-echo sequences of the ascending aorta were retrospectively reviewed in 1027 patients (726 males, 301 females). Aortic lumen area was segmented using a semi-automatic approach to calculate AAS values. Subgroup analysis was performed for patients with normal CMR, tetralogy of Fallot (ToF), and ischemic heart disease (IHD). Multivariate and post-hoc analyses were performed to evaluate the effect of age, gender, and CVD on AAS values. Shapiro-Wilk, three- and two-way ANOVA, Mann-Whitney U, and Spearman correlation statistics were used. Results Multivariate analysis showed significant differences in AAS among decades of age (p < 0.001), genders (p = 0.006) and CVD subgroups (p < 0.001) without interaction among these factors. A gender-related difference (higher AAS in females) was significant in ToF (p = 0.008), while an AAS reduction during aging was observed in all CVD subgroups. Post-hoc analysis showed a significantly lower AAS in ToF and IHD patients compared to subjects with normal CMR (p < 0.001). Conclusion Differences in age, gender, and CVD independently affect AAS. The lower AAS observed in ToF fosters its assessment during follow-up in adulthood. Future studies on causes and clinical implications of a higher AAS in females affected by ToF are warranted.",
keywords = "Aging, Ascending aorta, Ischemic heart disease, Magnetic resonance imaging, Tetralogy of Fallot",
author = "Marco Scarabello and Marina Codari and Francesco Secchi and Canna{\`o}, {Paola M.} and Marco Al{\`i} and {Di Leo}, Giovanni and Francesco Sardanelli",
year = "2018",
month = "2",
day = "1",
doi = "10.1016/j.ejrad.2017.12.002",
language = "English",
volume = "99",
pages = "34--39",
journal = "European Journal of Radiology",
issn = "0720-048X",
publisher = "Elsevier Ireland Ltd",

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TY - JOUR

T1 - Strain of ascending aorta on cardiac magnetic resonance in 1027 patients

T2 - Relation with age, gender, and cardiovascular disease

AU - Scarabello, Marco

AU - Codari, Marina

AU - Secchi, Francesco

AU - Cannaò, Paola M.

AU - Alì, Marco

AU - Di Leo, Giovanni

AU - Sardanelli, Francesco

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Objectives To evaluate ascending aortic strain (AAS) with cardiac magnetic resonance (CMR) in a large consecutive series of patients with different types of cardiovascular disease (CVD). Methods Two-dimensional phase-contrast gradient-echo sequences of the ascending aorta were retrospectively reviewed in 1027 patients (726 males, 301 females). Aortic lumen area was segmented using a semi-automatic approach to calculate AAS values. Subgroup analysis was performed for patients with normal CMR, tetralogy of Fallot (ToF), and ischemic heart disease (IHD). Multivariate and post-hoc analyses were performed to evaluate the effect of age, gender, and CVD on AAS values. Shapiro-Wilk, three- and two-way ANOVA, Mann-Whitney U, and Spearman correlation statistics were used. Results Multivariate analysis showed significant differences in AAS among decades of age (p < 0.001), genders (p = 0.006) and CVD subgroups (p < 0.001) without interaction among these factors. A gender-related difference (higher AAS in females) was significant in ToF (p = 0.008), while an AAS reduction during aging was observed in all CVD subgroups. Post-hoc analysis showed a significantly lower AAS in ToF and IHD patients compared to subjects with normal CMR (p < 0.001). Conclusion Differences in age, gender, and CVD independently affect AAS. The lower AAS observed in ToF fosters its assessment during follow-up in adulthood. Future studies on causes and clinical implications of a higher AAS in females affected by ToF are warranted.

AB - Objectives To evaluate ascending aortic strain (AAS) with cardiac magnetic resonance (CMR) in a large consecutive series of patients with different types of cardiovascular disease (CVD). Methods Two-dimensional phase-contrast gradient-echo sequences of the ascending aorta were retrospectively reviewed in 1027 patients (726 males, 301 females). Aortic lumen area was segmented using a semi-automatic approach to calculate AAS values. Subgroup analysis was performed for patients with normal CMR, tetralogy of Fallot (ToF), and ischemic heart disease (IHD). Multivariate and post-hoc analyses were performed to evaluate the effect of age, gender, and CVD on AAS values. Shapiro-Wilk, three- and two-way ANOVA, Mann-Whitney U, and Spearman correlation statistics were used. Results Multivariate analysis showed significant differences in AAS among decades of age (p < 0.001), genders (p = 0.006) and CVD subgroups (p < 0.001) without interaction among these factors. A gender-related difference (higher AAS in females) was significant in ToF (p = 0.008), while an AAS reduction during aging was observed in all CVD subgroups. Post-hoc analysis showed a significantly lower AAS in ToF and IHD patients compared to subjects with normal CMR (p < 0.001). Conclusion Differences in age, gender, and CVD independently affect AAS. The lower AAS observed in ToF fosters its assessment during follow-up in adulthood. Future studies on causes and clinical implications of a higher AAS in females affected by ToF are warranted.

KW - Aging

KW - Ascending aorta

KW - Ischemic heart disease

KW - Magnetic resonance imaging

KW - Tetralogy of Fallot

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JO - European Journal of Radiology

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