Strategic lesions in the anterior thalamic radiation and apathy in early Alzheimer's disease

Mario Torso, Laura Serra, Giovanni Giulietti, Barbara Spanò, Elisa Tuzzi, Giacomo Koch, Carlo Caltagirone, Mara Cercignani, Marco Bozzali

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: Behavioural disorders and psychological symptoms of Dementia (BPSD) are commonly observed in Alzheimer's disease (AD), and strongly contribute to increasing patients' disability. Using voxel-lesion-symptom mapping (VLSM), we investigated the impact of white matter lesions (WMLs) on the severity of BPSD in patients with amnestic mild cognitive impairment (a-MCI). Methods: Thirty-one a-MCI patients (with a conversion rate to AD of 32% at 2 year follow-up) and 26 healthy controls underwent magnetic resonance imaging (MRI) examination at 3T, including T2-weighted and fluid-attenuated-inversion-recovery images, and T1-weighted volumes. In the patient group, BPSD was assessed using the Neuropsychiatric Inventory-12. After quantitative definition of WMLs, their distribution was investigated, without an a priori anatomical hypothesis, against patients' behavioural symptoms. Unbiased regional grey matter volumetrics was also used to assess the contribution of grey matter atrophy to BPSD. Results: Apathy, irritability, depression/dysphoria, anxiety and agitation were shown to be the most common symptoms in the patient sample. Despite a more widespread anatomical distribution, a-MCI patients did not differ from controls in WML volumes. VLSM revealed a strict association between the presence of lesions in the anterior thalamic radiations (ATRs) and the severity of apathy. Regional grey matter atrophy did not account for any BPSD. Conclusions: This study indicates that damage to the ATRs is strategic for the occurrence of apathy in patients with a-MCI. Disconnection between the prefrontal cortex and the mediodorsal and anterior thalamic nuclei might represent the pathophysiological substrate for apathy, which is one of the most common psychopathological symptoms observed in dementia.

Original languageEnglish
Article numbere0124998
JournalPLoS One
Volume10
Issue number5
DOIs
Publication statusPublished - May 1 2015

Fingerprint

Apathy
Alzheimer disease
lesions (animal)
signs and symptoms (animals and humans)
Alzheimer Disease
dementia
Radiation
behavior disorders
Dementia
Magnetic resonance
Psychology
Imaging techniques
Recovery
Fluids
Substrates
Atrophy
atrophy
Anterior Thalamic Nuclei
Mediodorsal Thalamic Nucleus
Behavioral Symptoms

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Strategic lesions in the anterior thalamic radiation and apathy in early Alzheimer's disease. / Torso, Mario; Serra, Laura; Giulietti, Giovanni; Spanò, Barbara; Tuzzi, Elisa; Koch, Giacomo; Caltagirone, Carlo; Cercignani, Mara; Bozzali, Marco.

In: PLoS One, Vol. 10, No. 5, e0124998, 01.05.2015.

Research output: Contribution to journalArticle

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