Strategic targets of essential host-pathogen interactions

Francesco Blasi, Paolo Tarsia, Stefano Aliberti

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

This review summarizes the present concepts regarding the biological processes that mediate intrinsic and innate host defense against microbial invasion of the lung. Innate immunity is the first line of defense of the higher organisms towards invading pathogens. It accomplishes a wide variety of activities including recognition and effector functions. The innate responses use phagocytic cells (macrophages, monocytes, and neutrophils), cells that release inflammatory mediators (basophils, mast cells, and eosinophils), and natural killer cells. The molecular component of innate responses includes complement, acute-phase proteins, and cytokines. Recognition of pathogen-associated molecular patterns is mediated by the pathogen receptors of the innate immune system, among these molecules toll-like receptors have emerged as fundamental components in the innate immune responses to infection, and a link between innate and adaptive immunity. Additional protection comes from polypeptide mediators of the innate host defense, such as the defensins and other antibiotic peptides. In view of the considerable burden in terms of mortality and morbidity that severe infections still pose worldwide, a better understanding of the biological basis of host-pathogen interactions opens stimulating future treatment perspectives.

Original languageEnglish
Pages (from-to)9-25
Number of pages17
JournalRespiration
Volume72
Issue number1
DOIs
Publication statusPublished - Jan 2005

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Host-Pathogen Interactions
Innate Immunity
Defensins
Biological Phenomena
Peptides
Basophils
Acute-Phase Proteins
Toll-Like Receptors
Adaptive Immunity
Phagocytes
Infection
Eosinophils
Mast Cells
Natural Killer Cells
Monocytes
Immune System
Neutrophils
Macrophages
Cytokines
Anti-Bacterial Agents

Keywords

  • Antimicrobial peptides
  • Innate immunity
  • Surfactant proteins
  • Toll-like receptors

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Physiology

Cite this

Strategic targets of essential host-pathogen interactions. / Blasi, Francesco; Tarsia, Paolo; Aliberti, Stefano.

In: Respiration, Vol. 72, No. 1, 01.2005, p. 9-25.

Research output: Contribution to journalArticle

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