STrategically Acquired Gradient Echo (STAGE) imaging, part III: Technical advances and clinical applications of a rapid multi-contrast multi-parametric brain imaging method

E. Mark Haacke, Yongsheng Chen, David Utriainen, Bo Wu, Yu Wang, Shuang Xia, Naying He, Chunyan Zhang, Xiao Wang, M. Marcella Lagana, Yu Luo, Ali Fatemi, Saifeng Liu, Sara Gharabaghi, Dongmei Wu, Sean K. Sethi, Feng Huang, Taotao Sun, Feifei Qu, Brijesh K. YadavXiaoyue Ma, Yan Bai, Meiyun Wang, Jingliang Cheng, Fuhua Yan

Research output: Contribution to journalArticle

Abstract

One major thrust in radiology today is image standardization with a focus on rapidly acquired quantitative multi-contrast information. This is critical for multi-center trials, for the collection of big data and for the use of artificial intelligence in evaluating the data. Strategically acquired gradient echo (STAGE) imaging is one such method that can provide 8 qualitative and 7 quantitative pieces of information in 5 min or less at 3 T. STAGE provides qualitative images in the form of proton density weighted images, T1 weighted images, T2* weighted images and simulated double inversion recovery (DIR) images. STAGE also provides quantitative data in the form of proton spin density, T1, T2* and susceptibility maps as well as segmentation of white matter, gray matter and cerebrospinal fluid. STAGE uses vendors' product gradient echo sequences. It can be applied from 0.35 T to 7 T across all manufacturers producing similar results in contrast and quantification of the data. In this paper, we discuss the strengths and weaknesses of STAGE, demonstrate its contrast-to-noise (CNR) behavior relative to a large clinical data set and introduce a few new image contrasts derived from STAGE, including DIR images and a new concept referred to as true susceptibility weighted imaging (tSWI) linked to fluid attenuated inversion recovery (FLAIR) or tSWI-FLAIR for the evaluation of multiple sclerosis lesions. The robustness of STAGE T1 mapping was tested using the NIST/NIH phantom, while the reproducibility was tested by scanning a given individual ten times in one session and the same subject scanned once a week over a 12-week period. Assessment of the CNR for the enhanced T1W image (T1WE) showed a significantly better contrast between gray matter and white matter than conventional T1W images in both patients with Parkinson's disease and healthy controls. We also present some clinical cases using STAGE imaging in patients with stroke, metastasis, multiple sclerosis and a fetus with ventriculomegaly. Overall, STAGE is a comprehensive protocol that provides the clinician with numerous qualitative and quantitative images.

Original languageEnglish
Pages (from-to)15-26
Number of pages12
JournalMagnetic Resonance Imaging
Volume65
DOIs
Publication statusPublished - Jan 1 2020

Fingerprint

Neuroimaging
Multiple Sclerosis
Noise
Protons
Brain
Imaging techniques
Recovery
Artificial Intelligence
Radiology
Parkinson Disease
Cerebrospinal Fluid
Fetus
Stroke
Neoplasm Metastasis
Cerebrospinal fluid
Fluids
Standardization
Artificial intelligence
Scanning
Gray Matter

Keywords

  • Multi-parametric magnetic resonance imaging
  • Quantitative magnetic resonance imaging
  • Quantitative susceptibility mapping
  • Strategically acquired gradient echo
  • Susceptibility weighted imaging
  • T1 mapping

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Cite this

STrategically Acquired Gradient Echo (STAGE) imaging, part III : Technical advances and clinical applications of a rapid multi-contrast multi-parametric brain imaging method. / Haacke, E. Mark; Chen, Yongsheng; Utriainen, David; Wu, Bo; Wang, Yu; Xia, Shuang; He, Naying; Zhang, Chunyan; Wang, Xiao; Lagana, M. Marcella; Luo, Yu; Fatemi, Ali; Liu, Saifeng; Gharabaghi, Sara; Wu, Dongmei; Sethi, Sean K.; Huang, Feng; Sun, Taotao; Qu, Feifei; Yadav, Brijesh K.; Ma, Xiaoyue; Bai, Yan; Wang, Meiyun; Cheng, Jingliang; Yan, Fuhua.

In: Magnetic Resonance Imaging, Vol. 65, 01.01.2020, p. 15-26.

Research output: Contribution to journalArticle

Haacke, EM, Chen, Y, Utriainen, D, Wu, B, Wang, Y, Xia, S, He, N, Zhang, C, Wang, X, Lagana, MM, Luo, Y, Fatemi, A, Liu, S, Gharabaghi, S, Wu, D, Sethi, SK, Huang, F, Sun, T, Qu, F, Yadav, BK, Ma, X, Bai, Y, Wang, M, Cheng, J & Yan, F 2020, 'STrategically Acquired Gradient Echo (STAGE) imaging, part III: Technical advances and clinical applications of a rapid multi-contrast multi-parametric brain imaging method', Magnetic Resonance Imaging, vol. 65, pp. 15-26. https://doi.org/10.1016/j.mri.2019.09.006
Haacke, E. Mark ; Chen, Yongsheng ; Utriainen, David ; Wu, Bo ; Wang, Yu ; Xia, Shuang ; He, Naying ; Zhang, Chunyan ; Wang, Xiao ; Lagana, M. Marcella ; Luo, Yu ; Fatemi, Ali ; Liu, Saifeng ; Gharabaghi, Sara ; Wu, Dongmei ; Sethi, Sean K. ; Huang, Feng ; Sun, Taotao ; Qu, Feifei ; Yadav, Brijesh K. ; Ma, Xiaoyue ; Bai, Yan ; Wang, Meiyun ; Cheng, Jingliang ; Yan, Fuhua. / STrategically Acquired Gradient Echo (STAGE) imaging, part III : Technical advances and clinical applications of a rapid multi-contrast multi-parametric brain imaging method. In: Magnetic Resonance Imaging. 2020 ; Vol. 65. pp. 15-26.
@article{2c7afadedb02471889badbe54a05faa8,
title = "STrategically Acquired Gradient Echo (STAGE) imaging, part III: Technical advances and clinical applications of a rapid multi-contrast multi-parametric brain imaging method",
abstract = "One major thrust in radiology today is image standardization with a focus on rapidly acquired quantitative multi-contrast information. This is critical for multi-center trials, for the collection of big data and for the use of artificial intelligence in evaluating the data. Strategically acquired gradient echo (STAGE) imaging is one such method that can provide 8 qualitative and 7 quantitative pieces of information in 5 min or less at 3 T. STAGE provides qualitative images in the form of proton density weighted images, T1 weighted images, T2* weighted images and simulated double inversion recovery (DIR) images. STAGE also provides quantitative data in the form of proton spin density, T1, T2* and susceptibility maps as well as segmentation of white matter, gray matter and cerebrospinal fluid. STAGE uses vendors' product gradient echo sequences. It can be applied from 0.35 T to 7 T across all manufacturers producing similar results in contrast and quantification of the data. In this paper, we discuss the strengths and weaknesses of STAGE, demonstrate its contrast-to-noise (CNR) behavior relative to a large clinical data set and introduce a few new image contrasts derived from STAGE, including DIR images and a new concept referred to as true susceptibility weighted imaging (tSWI) linked to fluid attenuated inversion recovery (FLAIR) or tSWI-FLAIR for the evaluation of multiple sclerosis lesions. The robustness of STAGE T1 mapping was tested using the NIST/NIH phantom, while the reproducibility was tested by scanning a given individual ten times in one session and the same subject scanned once a week over a 12-week period. Assessment of the CNR for the enhanced T1W image (T1WE) showed a significantly better contrast between gray matter and white matter than conventional T1W images in both patients with Parkinson's disease and healthy controls. We also present some clinical cases using STAGE imaging in patients with stroke, metastasis, multiple sclerosis and a fetus with ventriculomegaly. Overall, STAGE is a comprehensive protocol that provides the clinician with numerous qualitative and quantitative images.",
keywords = "Multi-parametric magnetic resonance imaging, Quantitative magnetic resonance imaging, Quantitative susceptibility mapping, Strategically acquired gradient echo, Susceptibility weighted imaging, T1 mapping",
author = "Haacke, {E. Mark} and Yongsheng Chen and David Utriainen and Bo Wu and Yu Wang and Shuang Xia and Naying He and Chunyan Zhang and Xiao Wang and Lagana, {M. Marcella} and Yu Luo and Ali Fatemi and Saifeng Liu and Sara Gharabaghi and Dongmei Wu and Sethi, {Sean K.} and Feng Huang and Taotao Sun and Feifei Qu and Yadav, {Brijesh K.} and Xiaoyue Ma and Yan Bai and Meiyun Wang and Jingliang Cheng and Fuhua Yan",
year = "2020",
month = "1",
day = "1",
doi = "10.1016/j.mri.2019.09.006",
language = "English",
volume = "65",
pages = "15--26",
journal = "Magnetic Resonance Imaging",
issn = "0730-725X",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - STrategically Acquired Gradient Echo (STAGE) imaging, part III

T2 - Technical advances and clinical applications of a rapid multi-contrast multi-parametric brain imaging method

AU - Haacke, E. Mark

AU - Chen, Yongsheng

AU - Utriainen, David

AU - Wu, Bo

AU - Wang, Yu

AU - Xia, Shuang

AU - He, Naying

AU - Zhang, Chunyan

AU - Wang, Xiao

AU - Lagana, M. Marcella

AU - Luo, Yu

AU - Fatemi, Ali

AU - Liu, Saifeng

AU - Gharabaghi, Sara

AU - Wu, Dongmei

AU - Sethi, Sean K.

AU - Huang, Feng

AU - Sun, Taotao

AU - Qu, Feifei

AU - Yadav, Brijesh K.

AU - Ma, Xiaoyue

AU - Bai, Yan

AU - Wang, Meiyun

AU - Cheng, Jingliang

AU - Yan, Fuhua

PY - 2020/1/1

Y1 - 2020/1/1

N2 - One major thrust in radiology today is image standardization with a focus on rapidly acquired quantitative multi-contrast information. This is critical for multi-center trials, for the collection of big data and for the use of artificial intelligence in evaluating the data. Strategically acquired gradient echo (STAGE) imaging is one such method that can provide 8 qualitative and 7 quantitative pieces of information in 5 min or less at 3 T. STAGE provides qualitative images in the form of proton density weighted images, T1 weighted images, T2* weighted images and simulated double inversion recovery (DIR) images. STAGE also provides quantitative data in the form of proton spin density, T1, T2* and susceptibility maps as well as segmentation of white matter, gray matter and cerebrospinal fluid. STAGE uses vendors' product gradient echo sequences. It can be applied from 0.35 T to 7 T across all manufacturers producing similar results in contrast and quantification of the data. In this paper, we discuss the strengths and weaknesses of STAGE, demonstrate its contrast-to-noise (CNR) behavior relative to a large clinical data set and introduce a few new image contrasts derived from STAGE, including DIR images and a new concept referred to as true susceptibility weighted imaging (tSWI) linked to fluid attenuated inversion recovery (FLAIR) or tSWI-FLAIR for the evaluation of multiple sclerosis lesions. The robustness of STAGE T1 mapping was tested using the NIST/NIH phantom, while the reproducibility was tested by scanning a given individual ten times in one session and the same subject scanned once a week over a 12-week period. Assessment of the CNR for the enhanced T1W image (T1WE) showed a significantly better contrast between gray matter and white matter than conventional T1W images in both patients with Parkinson's disease and healthy controls. We also present some clinical cases using STAGE imaging in patients with stroke, metastasis, multiple sclerosis and a fetus with ventriculomegaly. Overall, STAGE is a comprehensive protocol that provides the clinician with numerous qualitative and quantitative images.

AB - One major thrust in radiology today is image standardization with a focus on rapidly acquired quantitative multi-contrast information. This is critical for multi-center trials, for the collection of big data and for the use of artificial intelligence in evaluating the data. Strategically acquired gradient echo (STAGE) imaging is one such method that can provide 8 qualitative and 7 quantitative pieces of information in 5 min or less at 3 T. STAGE provides qualitative images in the form of proton density weighted images, T1 weighted images, T2* weighted images and simulated double inversion recovery (DIR) images. STAGE also provides quantitative data in the form of proton spin density, T1, T2* and susceptibility maps as well as segmentation of white matter, gray matter and cerebrospinal fluid. STAGE uses vendors' product gradient echo sequences. It can be applied from 0.35 T to 7 T across all manufacturers producing similar results in contrast and quantification of the data. In this paper, we discuss the strengths and weaknesses of STAGE, demonstrate its contrast-to-noise (CNR) behavior relative to a large clinical data set and introduce a few new image contrasts derived from STAGE, including DIR images and a new concept referred to as true susceptibility weighted imaging (tSWI) linked to fluid attenuated inversion recovery (FLAIR) or tSWI-FLAIR for the evaluation of multiple sclerosis lesions. The robustness of STAGE T1 mapping was tested using the NIST/NIH phantom, while the reproducibility was tested by scanning a given individual ten times in one session and the same subject scanned once a week over a 12-week period. Assessment of the CNR for the enhanced T1W image (T1WE) showed a significantly better contrast between gray matter and white matter than conventional T1W images in both patients with Parkinson's disease and healthy controls. We also present some clinical cases using STAGE imaging in patients with stroke, metastasis, multiple sclerosis and a fetus with ventriculomegaly. Overall, STAGE is a comprehensive protocol that provides the clinician with numerous qualitative and quantitative images.

KW - Multi-parametric magnetic resonance imaging

KW - Quantitative magnetic resonance imaging

KW - Quantitative susceptibility mapping

KW - Strategically acquired gradient echo

KW - Susceptibility weighted imaging

KW - T1 mapping

UR - http://www.scopus.com/inward/record.url?scp=85073825816&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85073825816&partnerID=8YFLogxK

U2 - 10.1016/j.mri.2019.09.006

DO - 10.1016/j.mri.2019.09.006

M3 - Article

C2 - 31629075

AN - SCOPUS:85073825816

VL - 65

SP - 15

EP - 26

JO - Magnetic Resonance Imaging

JF - Magnetic Resonance Imaging

SN - 0730-725X

ER -