Strategies combining cells and scaffolds for bone tissue engineering

E. Saino, L. Fassina, V. Maliardi, M. S. Sbarra, M. G. Cusella De Angelis, G. Magenes, F. Benazzo, L. Visai

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Engineering bone typically uses highly porous scaffolds, osteoblasts or cells that can become osteoblasts, and regulating factors that promote cell attachment, differentiation, and mineralized bone formation. In this study we investigated the effects of the electromagnetic stimulation on SAOS-2 cells, from a human osteosarcoma cell line using a sintered 3D titanium scaffold. In comparison with control conditions (standard cell culture incubator, where no electromagnetic stimulus was detectable), the electromagnetic stimulus (magnetic field, 2 mT; frequency, 75 Hz) increased the cell proliferation and the surface coating with decorin, osteocalcin, osteopontin, and type-I collagen. The electromagnetic stimulus aimed at obtaining an improved cell proliferation and production of bone proteins, with a consequent surface coating of the scaffold. The protein-coated 3D titanium scaffold could be used, in clinical applications, as an implant for bone repair.

Original languageEnglish
Title of host publication12th International Conference on Fracture 2009, ICF-12
Number of pages8
Publication statusPublished - 2009
Event12th International Conference on Fracture 2009, ICF-12 - Ottawa, ON, Canada
Duration: Jul 12 2009Jul 17 2009


Other12th International Conference on Fracture 2009, ICF-12
CityOttawa, ON

ASJC Scopus subject areas

  • Geotechnical Engineering and Engineering Geology


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