Strategies for the characterization of the saccharidic moiety in composite nanoparticles

Carlo Morasso, Paolo Verderio, Miriam Colombo, Davide Prosperi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The exciting aptitude of sugars to form high-affinity interactions with various biological entities exploiting multivalency has led to the assessment of the potential of conjugating monoand oligosaccharides to nanoparticles to investigate the biorecognition events and interfere with biological processes involving carbohydrates. Since a critical step in these studies is the fine control on the presentation of the saccharide molecules, reliable methods to check their presence and, possibly, their arrangement on the surface of nanoparticles are urgently required. In this chapter, we provide an overview of the most common analytical techniques useful to characterize the saccharidic portion of glycoconjugate nanomaterials. Among them, HRMAS NMR looks particularly promising, as it can resolve the structures of the immobilized ligands and may provide information on their orientation on the nanoparticle surface.

Original languageEnglish
Title of host publicationACS Symposium Series
PublisherAmerican Chemical Society
Pages69-89
Number of pages21
Volume1091
ISBN (Print)9780841226883
DOIs
Publication statusPublished - 2011

Publication series

NameACS Symposium Series
Volume1091
ISSN (Print)00976156
ISSN (Electronic)19475918

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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