Strategies for the transfusion of subjects with complex red cell immunisation: The Bank of rare blood donors of the Region of Lombardy

Fernanda Morelati, Piera Arnaboldi, Fiorella Barocci, Umberto Bodini, Elisa Boiani, Susanna Bresciani, Giuseppe Cambiè, Giovanni Cazzaniga, Ernesto Cocco, Alessandro Copeta, Massimo Crotti, Francesco D'Agostino, Marco D'Agostino, Valeria Focchiatti, Elena Fonti, Luigi Galassi, Giambattista Gazzola, Luigi Gelpi, Noemi Greppi, Giovanni Battista InghilleriPaola Isernia, Maria Cristina Manera, Mirella Marini, Rosalia Monti, Rino Morales, Gianalessandro Moroni, Enrica Morra, Maria Paola Pau, Cinzia Paccapelo, Pasqualepaolo Pagliaro, Daniele Prati, Nicoletta Revelli, Claudia Rinaldini, Davide Rossi, Fabio Rossi, Laura Salvaneschi, Luca Sciariada, Pierluigi Sergiacomo, Alessandra Tiburzi, Roberta Trotti, Rosalia Turdo, Claudio Velati, Maria Antonietta Villa, Giuseppina Vismara, Elisabetta Vitali, Maurizio Marconi

Research output: Contribution to journalArticle

Abstract

Introduction. Selecting units of rare blood for transfusion to patients with complex immunisation is one of the most critical processes of a Transfusion Centre. In January 2005 the 'Rare Blood Components Bank - Reference Centre of the Region of Lombardy' w as established with the following goals: 1) identifying regional rare blood donors; 2) creating a regional registry of rare donors; 3) organising a regional bank of liquid and frozen rare blood units; 4) setting up a regional Immunohaematology Reference Laboratory (IRL) to type donors and resolve complex cases. Methods. The key elements in establishing the Bank were periodic meetings organised by the directors and representatives of the regional Departments of Transfusion Medicine and Haematology (DTMH) and the institution of three working groups (informatics, regulations, finance). Results. The regional IRL was set up, the relevant operating procedures were distributed region-wide, software features were defined and later validated upon activation, and the funds assigned were allocated to various cost items. The number and characteristics of the donors to be typed were identified and 14 regional DTMHs started to send samples. Overall, 20,714 donors were typed, for a total of 258,003 typings, and 2,880 rare donors were identified. Of these, 97% were rare donors because of combinations of antigens (2,139 negative for the S antigen and 659 negative for the s antigen) and 3% (n=82) because they were negative for high-frequency antigens. In the first 2 years of activity, the IRL carried out investigations of 140 complex cases referred from other Centres and distributed 2,024 units with rare phenotypes to 142 patients. Conclusions. The main goal achieved in the first 24 months from the start of the project was to set up a regional network able to meet the transfusion needs of patients with complex immunisation.

Original languageEnglish
Pages (from-to)217-226
Number of pages10
JournalBlood Transfusion
Volume5
Issue number4
DOIs
Publication statusPublished - 2007

Fingerprint

Blood Donors
Immunization
Tissue Donors
Antigens
Transfusion Medicine
Blood Banks
Informatics
Hematology
Financial Management
Blood Transfusion
Registries
Software
Phenotype
Costs and Cost Analysis

Keywords

  • Banks and registries of rare donors
  • Complex red cell immunisation
  • Transfusion support

ASJC Scopus subject areas

  • Hematology
  • Immunology and Allergy

Cite this

Strategies for the transfusion of subjects with complex red cell immunisation : The Bank of rare blood donors of the Region of Lombardy. / Morelati, Fernanda; Arnaboldi, Piera; Barocci, Fiorella; Bodini, Umberto; Boiani, Elisa; Bresciani, Susanna; Cambiè, Giuseppe; Cazzaniga, Giovanni; Cocco, Ernesto; Copeta, Alessandro; Crotti, Massimo; D'Agostino, Francesco; D'Agostino, Marco; Focchiatti, Valeria; Fonti, Elena; Galassi, Luigi; Gazzola, Giambattista; Gelpi, Luigi; Greppi, Noemi; Inghilleri, Giovanni Battista; Isernia, Paola; Manera, Maria Cristina; Marini, Mirella; Monti, Rosalia; Morales, Rino; Moroni, Gianalessandro; Morra, Enrica; Pau, Maria Paola; Paccapelo, Cinzia; Pagliaro, Pasqualepaolo; Prati, Daniele; Revelli, Nicoletta; Rinaldini, Claudia; Rossi, Davide; Rossi, Fabio; Salvaneschi, Laura; Sciariada, Luca; Sergiacomo, Pierluigi; Tiburzi, Alessandra; Trotti, Roberta; Turdo, Rosalia; Velati, Claudio; Villa, Maria Antonietta; Vismara, Giuseppina; Vitali, Elisabetta; Marconi, Maurizio.

In: Blood Transfusion, Vol. 5, No. 4, 2007, p. 217-226.

Research output: Contribution to journalArticle

Morelati, F, Arnaboldi, P, Barocci, F, Bodini, U, Boiani, E, Bresciani, S, Cambiè, G, Cazzaniga, G, Cocco, E, Copeta, A, Crotti, M, D'Agostino, F, D'Agostino, M, Focchiatti, V, Fonti, E, Galassi, L, Gazzola, G, Gelpi, L, Greppi, N, Inghilleri, GB, Isernia, P, Manera, MC, Marini, M, Monti, R, Morales, R, Moroni, G, Morra, E, Pau, MP, Paccapelo, C, Pagliaro, P, Prati, D, Revelli, N, Rinaldini, C, Rossi, D, Rossi, F, Salvaneschi, L, Sciariada, L, Sergiacomo, P, Tiburzi, A, Trotti, R, Turdo, R, Velati, C, Villa, MA, Vismara, G, Vitali, E & Marconi, M 2007, 'Strategies for the transfusion of subjects with complex red cell immunisation: The Bank of rare blood donors of the Region of Lombardy', Blood Transfusion, vol. 5, no. 4, pp. 217-226. https://doi.org/10.2450/2007.0016-07
Morelati, Fernanda ; Arnaboldi, Piera ; Barocci, Fiorella ; Bodini, Umberto ; Boiani, Elisa ; Bresciani, Susanna ; Cambiè, Giuseppe ; Cazzaniga, Giovanni ; Cocco, Ernesto ; Copeta, Alessandro ; Crotti, Massimo ; D'Agostino, Francesco ; D'Agostino, Marco ; Focchiatti, Valeria ; Fonti, Elena ; Galassi, Luigi ; Gazzola, Giambattista ; Gelpi, Luigi ; Greppi, Noemi ; Inghilleri, Giovanni Battista ; Isernia, Paola ; Manera, Maria Cristina ; Marini, Mirella ; Monti, Rosalia ; Morales, Rino ; Moroni, Gianalessandro ; Morra, Enrica ; Pau, Maria Paola ; Paccapelo, Cinzia ; Pagliaro, Pasqualepaolo ; Prati, Daniele ; Revelli, Nicoletta ; Rinaldini, Claudia ; Rossi, Davide ; Rossi, Fabio ; Salvaneschi, Laura ; Sciariada, Luca ; Sergiacomo, Pierluigi ; Tiburzi, Alessandra ; Trotti, Roberta ; Turdo, Rosalia ; Velati, Claudio ; Villa, Maria Antonietta ; Vismara, Giuseppina ; Vitali, Elisabetta ; Marconi, Maurizio. / Strategies for the transfusion of subjects with complex red cell immunisation : The Bank of rare blood donors of the Region of Lombardy. In: Blood Transfusion. 2007 ; Vol. 5, No. 4. pp. 217-226.
@article{9c36ee614584473f81e8aa11e795e8f0,
title = "Strategies for the transfusion of subjects with complex red cell immunisation: The Bank of rare blood donors of the Region of Lombardy",
abstract = "Introduction. Selecting units of rare blood for transfusion to patients with complex immunisation is one of the most critical processes of a Transfusion Centre. In January 2005 the 'Rare Blood Components Bank - Reference Centre of the Region of Lombardy' w as established with the following goals: 1) identifying regional rare blood donors; 2) creating a regional registry of rare donors; 3) organising a regional bank of liquid and frozen rare blood units; 4) setting up a regional Immunohaematology Reference Laboratory (IRL) to type donors and resolve complex cases. Methods. The key elements in establishing the Bank were periodic meetings organised by the directors and representatives of the regional Departments of Transfusion Medicine and Haematology (DTMH) and the institution of three working groups (informatics, regulations, finance). Results. The regional IRL was set up, the relevant operating procedures were distributed region-wide, software features were defined and later validated upon activation, and the funds assigned were allocated to various cost items. The number and characteristics of the donors to be typed were identified and 14 regional DTMHs started to send samples. Overall, 20,714 donors were typed, for a total of 258,003 typings, and 2,880 rare donors were identified. Of these, 97{\%} were rare donors because of combinations of antigens (2,139 negative for the S antigen and 659 negative for the s antigen) and 3{\%} (n=82) because they were negative for high-frequency antigens. In the first 2 years of activity, the IRL carried out investigations of 140 complex cases referred from other Centres and distributed 2,024 units with rare phenotypes to 142 patients. Conclusions. The main goal achieved in the first 24 months from the start of the project was to set up a regional network able to meet the transfusion needs of patients with complex immunisation.",
keywords = "Banks and registries of rare donors, Complex red cell immunisation, Transfusion support",
author = "Fernanda Morelati and Piera Arnaboldi and Fiorella Barocci and Umberto Bodini and Elisa Boiani and Susanna Bresciani and Giuseppe Cambi{\`e} and Giovanni Cazzaniga and Ernesto Cocco and Alessandro Copeta and Massimo Crotti and Francesco D'Agostino and Marco D'Agostino and Valeria Focchiatti and Elena Fonti and Luigi Galassi and Giambattista Gazzola and Luigi Gelpi and Noemi Greppi and Inghilleri, {Giovanni Battista} and Paola Isernia and Manera, {Maria Cristina} and Mirella Marini and Rosalia Monti and Rino Morales and Gianalessandro Moroni and Enrica Morra and Pau, {Maria Paola} and Cinzia Paccapelo and Pasqualepaolo Pagliaro and Daniele Prati and Nicoletta Revelli and Claudia Rinaldini and Davide Rossi and Fabio Rossi and Laura Salvaneschi and Luca Sciariada and Pierluigi Sergiacomo and Alessandra Tiburzi and Roberta Trotti and Rosalia Turdo and Claudio Velati and Villa, {Maria Antonietta} and Giuseppina Vismara and Elisabetta Vitali and Maurizio Marconi",
year = "2007",
doi = "10.2450/2007.0016-07",
language = "English",
volume = "5",
pages = "217--226",
journal = "Blood Transfusion",
issn = "1723-2007",
publisher = "Edizioni SIMTI",
number = "4",

}

TY - JOUR

T1 - Strategies for the transfusion of subjects with complex red cell immunisation

T2 - The Bank of rare blood donors of the Region of Lombardy

AU - Morelati, Fernanda

AU - Arnaboldi, Piera

AU - Barocci, Fiorella

AU - Bodini, Umberto

AU - Boiani, Elisa

AU - Bresciani, Susanna

AU - Cambiè, Giuseppe

AU - Cazzaniga, Giovanni

AU - Cocco, Ernesto

AU - Copeta, Alessandro

AU - Crotti, Massimo

AU - D'Agostino, Francesco

AU - D'Agostino, Marco

AU - Focchiatti, Valeria

AU - Fonti, Elena

AU - Galassi, Luigi

AU - Gazzola, Giambattista

AU - Gelpi, Luigi

AU - Greppi, Noemi

AU - Inghilleri, Giovanni Battista

AU - Isernia, Paola

AU - Manera, Maria Cristina

AU - Marini, Mirella

AU - Monti, Rosalia

AU - Morales, Rino

AU - Moroni, Gianalessandro

AU - Morra, Enrica

AU - Pau, Maria Paola

AU - Paccapelo, Cinzia

AU - Pagliaro, Pasqualepaolo

AU - Prati, Daniele

AU - Revelli, Nicoletta

AU - Rinaldini, Claudia

AU - Rossi, Davide

AU - Rossi, Fabio

AU - Salvaneschi, Laura

AU - Sciariada, Luca

AU - Sergiacomo, Pierluigi

AU - Tiburzi, Alessandra

AU - Trotti, Roberta

AU - Turdo, Rosalia

AU - Velati, Claudio

AU - Villa, Maria Antonietta

AU - Vismara, Giuseppina

AU - Vitali, Elisabetta

AU - Marconi, Maurizio

PY - 2007

Y1 - 2007

N2 - Introduction. Selecting units of rare blood for transfusion to patients with complex immunisation is one of the most critical processes of a Transfusion Centre. In January 2005 the 'Rare Blood Components Bank - Reference Centre of the Region of Lombardy' w as established with the following goals: 1) identifying regional rare blood donors; 2) creating a regional registry of rare donors; 3) organising a regional bank of liquid and frozen rare blood units; 4) setting up a regional Immunohaematology Reference Laboratory (IRL) to type donors and resolve complex cases. Methods. The key elements in establishing the Bank were periodic meetings organised by the directors and representatives of the regional Departments of Transfusion Medicine and Haematology (DTMH) and the institution of three working groups (informatics, regulations, finance). Results. The regional IRL was set up, the relevant operating procedures were distributed region-wide, software features were defined and later validated upon activation, and the funds assigned were allocated to various cost items. The number and characteristics of the donors to be typed were identified and 14 regional DTMHs started to send samples. Overall, 20,714 donors were typed, for a total of 258,003 typings, and 2,880 rare donors were identified. Of these, 97% were rare donors because of combinations of antigens (2,139 negative for the S antigen and 659 negative for the s antigen) and 3% (n=82) because they were negative for high-frequency antigens. In the first 2 years of activity, the IRL carried out investigations of 140 complex cases referred from other Centres and distributed 2,024 units with rare phenotypes to 142 patients. Conclusions. The main goal achieved in the first 24 months from the start of the project was to set up a regional network able to meet the transfusion needs of patients with complex immunisation.

AB - Introduction. Selecting units of rare blood for transfusion to patients with complex immunisation is one of the most critical processes of a Transfusion Centre. In January 2005 the 'Rare Blood Components Bank - Reference Centre of the Region of Lombardy' w as established with the following goals: 1) identifying regional rare blood donors; 2) creating a regional registry of rare donors; 3) organising a regional bank of liquid and frozen rare blood units; 4) setting up a regional Immunohaematology Reference Laboratory (IRL) to type donors and resolve complex cases. Methods. The key elements in establishing the Bank were periodic meetings organised by the directors and representatives of the regional Departments of Transfusion Medicine and Haematology (DTMH) and the institution of three working groups (informatics, regulations, finance). Results. The regional IRL was set up, the relevant operating procedures were distributed region-wide, software features were defined and later validated upon activation, and the funds assigned were allocated to various cost items. The number and characteristics of the donors to be typed were identified and 14 regional DTMHs started to send samples. Overall, 20,714 donors were typed, for a total of 258,003 typings, and 2,880 rare donors were identified. Of these, 97% were rare donors because of combinations of antigens (2,139 negative for the S antigen and 659 negative for the s antigen) and 3% (n=82) because they were negative for high-frequency antigens. In the first 2 years of activity, the IRL carried out investigations of 140 complex cases referred from other Centres and distributed 2,024 units with rare phenotypes to 142 patients. Conclusions. The main goal achieved in the first 24 months from the start of the project was to set up a regional network able to meet the transfusion needs of patients with complex immunisation.

KW - Banks and registries of rare donors

KW - Complex red cell immunisation

KW - Transfusion support

UR - http://www.scopus.com/inward/record.url?scp=47749105650&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=47749105650&partnerID=8YFLogxK

U2 - 10.2450/2007.0016-07

DO - 10.2450/2007.0016-07

M3 - Article

C2 - 19204778

AN - SCOPUS:47749105650

VL - 5

SP - 217

EP - 226

JO - Blood Transfusion

JF - Blood Transfusion

SN - 1723-2007

IS - 4

ER -