Abstract
Introduction. Selecting units of rare blood for transfusion to patients with complex immunisation is one of the most critical processes of a Transfusion Centre. In January 2005 the 'Rare Blood Components Bank - Reference Centre of the Region of Lombardy' w as established with the following goals: 1) identifying regional rare blood donors; 2) creating a regional registry of rare donors; 3) organising a regional bank of liquid and frozen rare blood units; 4) setting up a regional Immunohaematology Reference Laboratory (IRL) to type donors and resolve complex cases. Methods. The key elements in establishing the Bank were periodic meetings organised by the directors and representatives of the regional Departments of Transfusion Medicine and Haematology (DTMH) and the institution of three working groups (informatics, regulations, finance). Results. The regional IRL was set up, the relevant operating procedures were distributed region-wide, software features were defined and later validated upon activation, and the funds assigned were allocated to various cost items. The number and characteristics of the donors to be typed were identified and 14 regional DTMHs started to send samples. Overall, 20,714 donors were typed, for a total of 258,003 typings, and 2,880 rare donors were identified. Of these, 97% were rare donors because of combinations of antigens (2,139 negative for the S antigen and 659 negative for the s antigen) and 3% (n=82) because they were negative for high-frequency antigens. In the first 2 years of activity, the IRL carried out investigations of 140 complex cases referred from other Centres and distributed 2,024 units with rare phenotypes to 142 patients. Conclusions. The main goal achieved in the first 24 months from the start of the project was to set up a regional network able to meet the transfusion needs of patients with complex immunisation.
| Original language | English |
|---|---|
| Pages (from-to) | 217-226 |
| Number of pages | 10 |
| Journal | Blood Transfusion |
| Volume | 5 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2007 |
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Keywords
- Banks and registries of rare donors
- Complex red cell immunisation
- Transfusion support
ASJC Scopus subject areas
- Hematology
- Immunology and Allergy
Cite this
Strategies for the transfusion of subjects with complex red cell immunisation : The Bank of rare blood donors of the Region of Lombardy. / Morelati, Fernanda; Arnaboldi, Piera; Barocci, Fiorella; Bodini, Umberto; Boiani, Elisa; Bresciani, Susanna; Cambiè, Giuseppe; Cazzaniga, Giovanni; Cocco, Ernesto; Copeta, Alessandro; Crotti, Massimo; D'Agostino, Francesco; D'Agostino, Marco; Focchiatti, Valeria; Fonti, Elena; Galassi, Luigi; Gazzola, Giambattista; Gelpi, Luigi; Greppi, Noemi; Inghilleri, Giovanni Battista; Isernia, Paola; Manera, Maria Cristina; Marini, Mirella; Monti, Rosalia; Morales, Rino; Moroni, Gianalessandro; Morra, Enrica; Pau, Maria Paola; Paccapelo, Cinzia; Pagliaro, Pasqualepaolo; Prati, Daniele; Revelli, Nicoletta; Rinaldini, Claudia; Rossi, Davide; Rossi, Fabio; Salvaneschi, Laura; Sciariada, Luca; Sergiacomo, Pierluigi; Tiburzi, Alessandra; Trotti, Roberta; Turdo, Rosalia; Velati, Claudio; Villa, Maria Antonietta; Vismara, Giuseppina; Vitali, Elisabetta; Marconi, Maurizio.
In: Blood Transfusion, Vol. 5, No. 4, 2007, p. 217-226.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Strategies for the transfusion of subjects with complex red cell immunisation
T2 - The Bank of rare blood donors of the Region of Lombardy
AU - Morelati, Fernanda
AU - Arnaboldi, Piera
AU - Barocci, Fiorella
AU - Bodini, Umberto
AU - Boiani, Elisa
AU - Bresciani, Susanna
AU - Cambiè, Giuseppe
AU - Cazzaniga, Giovanni
AU - Cocco, Ernesto
AU - Copeta, Alessandro
AU - Crotti, Massimo
AU - D'Agostino, Francesco
AU - D'Agostino, Marco
AU - Focchiatti, Valeria
AU - Fonti, Elena
AU - Galassi, Luigi
AU - Gazzola, Giambattista
AU - Gelpi, Luigi
AU - Greppi, Noemi
AU - Inghilleri, Giovanni Battista
AU - Isernia, Paola
AU - Manera, Maria Cristina
AU - Marini, Mirella
AU - Monti, Rosalia
AU - Morales, Rino
AU - Moroni, Gianalessandro
AU - Morra, Enrica
AU - Pau, Maria Paola
AU - Paccapelo, Cinzia
AU - Pagliaro, Pasqualepaolo
AU - Prati, Daniele
AU - Revelli, Nicoletta
AU - Rinaldini, Claudia
AU - Rossi, Davide
AU - Rossi, Fabio
AU - Salvaneschi, Laura
AU - Sciariada, Luca
AU - Sergiacomo, Pierluigi
AU - Tiburzi, Alessandra
AU - Trotti, Roberta
AU - Turdo, Rosalia
AU - Velati, Claudio
AU - Villa, Maria Antonietta
AU - Vismara, Giuseppina
AU - Vitali, Elisabetta
AU - Marconi, Maurizio
PY - 2007
Y1 - 2007
N2 - Introduction. Selecting units of rare blood for transfusion to patients with complex immunisation is one of the most critical processes of a Transfusion Centre. In January 2005 the 'Rare Blood Components Bank - Reference Centre of the Region of Lombardy' w as established with the following goals: 1) identifying regional rare blood donors; 2) creating a regional registry of rare donors; 3) organising a regional bank of liquid and frozen rare blood units; 4) setting up a regional Immunohaematology Reference Laboratory (IRL) to type donors and resolve complex cases. Methods. The key elements in establishing the Bank were periodic meetings organised by the directors and representatives of the regional Departments of Transfusion Medicine and Haematology (DTMH) and the institution of three working groups (informatics, regulations, finance). Results. The regional IRL was set up, the relevant operating procedures were distributed region-wide, software features were defined and later validated upon activation, and the funds assigned were allocated to various cost items. The number and characteristics of the donors to be typed were identified and 14 regional DTMHs started to send samples. Overall, 20,714 donors were typed, for a total of 258,003 typings, and 2,880 rare donors were identified. Of these, 97% were rare donors because of combinations of antigens (2,139 negative for the S antigen and 659 negative for the s antigen) and 3% (n=82) because they were negative for high-frequency antigens. In the first 2 years of activity, the IRL carried out investigations of 140 complex cases referred from other Centres and distributed 2,024 units with rare phenotypes to 142 patients. Conclusions. The main goal achieved in the first 24 months from the start of the project was to set up a regional network able to meet the transfusion needs of patients with complex immunisation.
AB - Introduction. Selecting units of rare blood for transfusion to patients with complex immunisation is one of the most critical processes of a Transfusion Centre. In January 2005 the 'Rare Blood Components Bank - Reference Centre of the Region of Lombardy' w as established with the following goals: 1) identifying regional rare blood donors; 2) creating a regional registry of rare donors; 3) organising a regional bank of liquid and frozen rare blood units; 4) setting up a regional Immunohaematology Reference Laboratory (IRL) to type donors and resolve complex cases. Methods. The key elements in establishing the Bank were periodic meetings organised by the directors and representatives of the regional Departments of Transfusion Medicine and Haematology (DTMH) and the institution of three working groups (informatics, regulations, finance). Results. The regional IRL was set up, the relevant operating procedures were distributed region-wide, software features were defined and later validated upon activation, and the funds assigned were allocated to various cost items. The number and characteristics of the donors to be typed were identified and 14 regional DTMHs started to send samples. Overall, 20,714 donors were typed, for a total of 258,003 typings, and 2,880 rare donors were identified. Of these, 97% were rare donors because of combinations of antigens (2,139 negative for the S antigen and 659 negative for the s antigen) and 3% (n=82) because they were negative for high-frequency antigens. In the first 2 years of activity, the IRL carried out investigations of 140 complex cases referred from other Centres and distributed 2,024 units with rare phenotypes to 142 patients. Conclusions. The main goal achieved in the first 24 months from the start of the project was to set up a regional network able to meet the transfusion needs of patients with complex immunisation.
KW - Banks and registries of rare donors
KW - Complex red cell immunisation
KW - Transfusion support
UR - http://www.scopus.com/inward/record.url?scp=47749105650&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=47749105650&partnerID=8YFLogxK
U2 - 10.2450/2007.0016-07
DO - 10.2450/2007.0016-07
M3 - Article
C2 - 19204778
AN - SCOPUS:47749105650
VL - 5
SP - 217
EP - 226
JO - Blood Transfusion
JF - Blood Transfusion
SN - 1723-2007
IS - 4
ER -