Strategies for the treatment of autonomic trigeminal cephalalgias

M. Leone, A. Franzini, D. D'Amico, L. Grazzi, E. Mea, M. Curone, V. Tullo, G. Broggi, G. D'Andrea, G. Bussone

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Trigeminal autonomic cephalalgias (TACs) are a group of primary headache syndromes characterised by two main clinical characteristics: pain and oculofacial autonomic phenomena. Three headache forms are grouped as TACs: cluster headache (CH), paroxysmal hemicrania (PH) and short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) [1]. These are distinguished mainly on the basis of attack duration. It lasts from 15 to 180 min in CH, from 2 to 30 min in PH and from 5 to 240 s in SUNCT. The most effective drug preventative in PH is indomethacin even if in few cases other non-steroidal anti-inflammatory drugs have been reported to be effective [2]. SUNCT is commonly described as drug resistant. Recent studies report that lamotrigin may be the drug of choice for SUNCT [3, 4].

Original languageEnglish
JournalNeurological Sciences
Issue numberSUPPL. 3
Publication statusPublished - Oct 2004


  • Cluster headache
  • Deep brain stimulation
  • Paroxysmal hemicrania
  • Therapy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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