Strategies to accelerate immune recovery after allogeneic hematopoietic stem cell transplantation

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11 Citations (Scopus)

Abstract

The interplay existing between immune reconstitution and patient outcome has been extensively demonstrated in allogeneic hematopoietic stem cell transplantation. One of the leading causes of infection-related mortality is the slow recovery of T-cell immunity due to the conditioning regimen and/or age-related thymus damage, poor naïve T-cell output, and restricted T-cell receptor (TCR) repertoires. With the aim of improving posttransplantation immune reconstitution, several immunotherapy approaches have been explored. Donor leukocyte infusions are widely used to accelerate immune recovery, but they carry the risk of provoking graft-versus-host disease. This review will focus on sophisticated strategies of thymus function-recovery, adoptive infusion of donor-derived, allodepleted T cells, T-cell lines/clones specific for life-threatening pathogens, regulatory T cells, and of T cells transduced with suicide genes.

Original languageEnglish
Pages (from-to)343-358
Number of pages16
JournalExpert Review of Clinical Immunology
Volume12
Issue number3
DOIs
Publication statusPublished - Mar 3 2016

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Hematopoietic Stem Cell Transplantation
T-Lymphocytes
Transgenic Suicide Genes
Thymus Gland
Tissue Donors
Recovery of Function
Graft vs Host Disease
Regulatory T-Lymphocytes
T-Cell Antigen Receptor
Immunotherapy
Immunity
Leukocytes
Clone Cells
Cell Line
Mortality
Infection

Keywords

  • donor leukocyte infusion
  • hematopoietic stem cell transplantation
  • Immune reconstitution
  • T-cell immunotherapy
  • thymus function

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

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abstract = "The interplay existing between immune reconstitution and patient outcome has been extensively demonstrated in allogeneic hematopoietic stem cell transplantation. One of the leading causes of infection-related mortality is the slow recovery of T-cell immunity due to the conditioning regimen and/or age-related thymus damage, poor na{\"i}ve T-cell output, and restricted T-cell receptor (TCR) repertoires. With the aim of improving posttransplantation immune reconstitution, several immunotherapy approaches have been explored. Donor leukocyte infusions are widely used to accelerate immune recovery, but they carry the risk of provoking graft-versus-host disease. This review will focus on sophisticated strategies of thymus function-recovery, adoptive infusion of donor-derived, allodepleted T cells, T-cell lines/clones specific for life-threatening pathogens, regulatory T cells, and of T cells transduced with suicide genes.",
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AU - Merli, Pietro

AU - Bertaina, Valentina

AU - Locatelli, Franco

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