Strategies to develop vaccines of pediatric interest

Susanna Esposito, Nicola Principi, European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Vaccine Study Group (EVASG)

Research output: Contribution to journalReview articlepeer-review


Introduction: The success of the vaccines available on the market has significantly increased interest in vaccine development. Areas covered: The main aim of this paper is to discuss the most important vaccines of pediatric interest that are currently being developed. New pneumococcal vaccines and vaccines against group B Streptococcus, Staphylococcus aureus and respiratory syncytial virus are analyzed in detail. Expert commentary: Advances in understanding human immunology, including human monoclonal antibody identification, sequencing technology, and the ability to solve atomic level structures of vaccine targets have provided tools to guide the rational design of future vaccines. It is likely that some of these vaccines will reach the market in the future and will thus partially contribute to the prevention of very severe diseases that significantly affect the morbidity and mortality of children. However, further studies in animals and several clinical trials in children must be performed before new vaccines become licensed.

Original languageEnglish
Pages (from-to)175-186
Number of pages12
JournalExpert Review of Vaccines
Issue number2
Publication statusPublished - Feb 1 2017


  • Children
  • group B Streptococcus
  • prevention
  • RSV
  • Staphylococcus aureus
  • Streptococcus pneumoniae
  • vaccine

ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery


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