Abstract
HIV-1 infection leads to AIDS and death within 8-10 years for most individuals in the absence of antiretroviral therapy (ART). However, a minority of infected individuals show the unusual capacity to spontaneously control disease progression after infection in the absence of any ART. So-called 'long-term nonprogressors' are defined by maintenance of peripheral CD4 + T-cell counts >500 cells/μl and good health without ART for >7 years since infection. More recently, ART-naive individuals who spontaneously control their viremia levels at either
Original language | English |
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Pages (from-to) | 521-533 |
Number of pages | 13 |
Journal | Future Virology |
Volume | 6 |
Issue number | 4 |
DOIs | |
Publication status | Published - Apr 2011 |
Keywords
- AIDS
- ART
- elite controllers
- genome-wide association study
- HIV
- HIV controllers
- HLA
- long-term nonprogressors
- viremia
ASJC Scopus subject areas
- Virology