Strenuous resistance to natural HIV-1 disease progression: Viral controllers and long-term nonprogressors

Agostino Riva, Elisa Vicenzi, Massimo Galli, Guido Poli

Research output: Contribution to journalArticle

Abstract

HIV-1 infection leads to AIDS and death within 8-10 years for most individuals in the absence of antiretroviral therapy (ART). However, a minority of infected individuals show the unusual capacity to spontaneously control disease progression after infection in the absence of any ART. So-called 'long-term nonprogressors' are defined by maintenance of peripheral CD4 + T-cell counts >500 cells/μl and good health without ART for >7 years since infection. More recently, ART-naive individuals who spontaneously control their viremia levels at either

Original languageEnglish
Pages (from-to)521-533
Number of pages13
JournalFuture Virology
Volume6
Issue number4
DOIs
Publication statusPublished - Apr 2011

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Keywords

  • AIDS
  • ART
  • elite controllers
  • genome-wide association study
  • HIV
  • HIV controllers
  • HLA
  • long-term nonprogressors
  • viremia

ASJC Scopus subject areas

  • Virology

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