Streptococcus pneumoniae colonisation in children and adolescents with asthma: Impact of the heptavalent pneumococcal conjugate vaccine and evaluation of potential effect of thirteen-valent pneumococcal conjugate vaccine

Susanna Esposito, Leonardo Terranova, Maria Francesca Patria, Gian Luigi Marseglia, Michele Miraglia del Giudice, Alessandro Bodini, Alberto Martelli, Eugenio Baraldi, Oscar Mazzina, Claudia Tagliabue, Amelia Licari, Valentina Ierardi, Mara Lelii, Nicola Principi

Research output: Contribution to journalArticle

Abstract

Background: The main aim of this study was to evaluate Streptococcus pneumoniae carriage in a group of school-aged children and adolescents with asthma because these results might indicate the theoretical risk of invasive pneumococcal disease (IPD) of such patients and the potential protective efficacy of the 13-valent pneumococcal conjugate vaccine (PCV13). Methods: Oropharyngeal samples were obtained from 423 children with documented asthma (300 males, 70.9%), and tested for the autolysin-A-encoding (lytA) and the wzg (cpsA) gene of S. pneumoniae by means of real-time polymerase chain reaction. Results: S. pneumoniae was identified in the swabs of 192 subjects (45.4%): 48.4% of whom were aged

Original languageEnglish
Article number12
JournalBMC Infectious Diseases
Volume16
Issue number1
DOIs
Publication statusPublished - Jan 12 2016

Keywords

  • Asthma
  • Asthmatic children
  • Chronic respiratory disease
  • PCV13
  • PCV7
  • Pneumococcal colonisation
  • Pneumococcal conjugate vaccine
  • Pulmonary disease
  • Streptococcus pneumoniae

ASJC Scopus subject areas

  • Infectious Diseases

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