Streptococcus pneumoniae in western Europe: serotype distribution and incidence in children less than 2 years old

Tom Jefferson, Eliana Ferroni, Filippo Curtale, Paolo Giorgi Rossi, Piero Borgia

Research output: Contribution to journalArticle

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Abstract

We did a systematic search and synthesis of evidence on the incidence of invasive pneumococcal disease, symptomatic disease, and circulating Streptococcus pneumoniae serotypes in western Europe. Using data from studies published between 1992 and 2005 we calculated a weighted mean invasive pneumococcal disease and pneumococcal meningitis incidence rate per 100 000 children aged 2 years or younger within 95% confidence intervals, together with the prevalence of S pneumoniae serotypes and resistance to penicillin. Invasive pneumococcal disease incidence was 27·03 cases per 100 000 children under 2 years (95% CI 2·85-33·43). Heptavalent conjugate vaccine serotypes account for 43·18-75·32% of isolates among people aged under 18 years of age. 11% of isolates in individuals aged under 18 years were penicillin resistant. The incidence of invasive pneumococcal disease appeared consistently lower in western European countries compared with studies from the USA. Thus the use of studies of vaccine effectiveness based on the US population may lead to an overestimation of the benefits of its introduction in Europe.

Original languageEnglish
Pages (from-to)405-410
Number of pages6
JournalThe Lancet Infectious Diseases
Volume6
Issue number7
DOIs
Publication statusPublished - Jul 2006

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Streptococcus pneumoniae
Incidence
Pneumococcal Meningitis
Penicillin Resistance
Conjugate Vaccines
Penicillins
Pneumonia
Vaccines
Serogroup
Confidence Intervals
Population

ASJC Scopus subject areas

  • Infectious Diseases

Cite this

Streptococcus pneumoniae in western Europe : serotype distribution and incidence in children less than 2 years old. / Jefferson, Tom; Ferroni, Eliana; Curtale, Filippo; Giorgi Rossi, Paolo; Borgia, Piero.

In: The Lancet Infectious Diseases, Vol. 6, No. 7, 07.2006, p. 405-410.

Research output: Contribution to journalArticle

Jefferson, Tom ; Ferroni, Eliana ; Curtale, Filippo ; Giorgi Rossi, Paolo ; Borgia, Piero. / Streptococcus pneumoniae in western Europe : serotype distribution and incidence in children less than 2 years old. In: The Lancet Infectious Diseases. 2006 ; Vol. 6, No. 7. pp. 405-410.
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