Streptococcus pneumoniae oropharyngeal colonization in children and adolescents with cystic fibrosis

Susanna Esposito; Carla Colombo; Antonella Tosco; Enza Montemitro; Sonia Volpi; Luca Ruggiero; Mara Lelii; Arianna Bisogno; Claudio Pelucchi; Nicola Principi; Italian Pneumococcal Study Group on Cystic Fibrosis

doi:10.1016/j.jcf.2015.05.008

Streptococcus pneumoniae oropharyngeal colonization in children and adolescents with cystic fibrosis

Susanna Esposito, Carla Colombo, Antonella Tosco, Enza Montemitro, Sonia Volpi, Luca Ruggiero, Mara Lelii, Arianna Bisogno, Claudio Pelucchi, Nicola Principi, Italian Pneumococcal Study Group on Cystic Fibrosis

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: This study was designed to evaluate Streptococcus pneumoniae (S. pneumoniae) carriage rates in patients with cystic fibrosis (CF).

METHODS: An oropharyngeal swab was obtained from 212 CF children and adolescents enrolled during routine clinical visits. DNA from swabs was analyzed by real-time polymerase chain reaction.

RESULTS: A total of 42 (19.8%) CF patients (mean age±standard deviation [SD], 12.0±3.3years) were colonized by S. pneumoniae. Carriage was more common in younger patients and tended to decline with age. Administration of systemic and/or inhaled antibiotics in the last 3months significantly correlated with a reduced carrier state [odds ratio (OR) 0.23, 95% confidence interval (CI) 0.07-0.69, and OR 0.26, 95% CI 0.08-0.77, respectively]. Vitamin D serum levels ≥30ng/mL were less common in carriers than that in non-carriers (OR 0.35; 95% CI 0.08-1.49). In both the vaccinated and unvaccinated subjects, serotypes 19F, 5, 4, and 9V were the most commonly carried serotypes.

CONCLUSIONS: S. pneumoniae carrier state of school-age children and adolescents with CF is more prevalent than previously thought, and pneumococcal conjugate vaccination administered in the first year of life does not reduce the risk of re-colonization in later childhood and adolescence.

Original language	English
Pages (from-to)	366-71
Number of pages	6
Journal	Journal of Cystic Fibrosis
Volume	15
Issue number	3
DOIs	https://doi.org/10.1016/j.jcf.2015.05.008
Publication status	Published - May 2016

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Journal Article

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Esposito, S., Colombo, C., Tosco, A., Montemitro, E., Volpi, S., Ruggiero, L., Lelii, M., Bisogno, A., Pelucchi, C., Principi, N., & Italian Pneumococcal Study Group on Cystic Fibrosis (2016). Streptococcus pneumoniae oropharyngeal colonization in children and adolescents with cystic fibrosis. Journal of Cystic Fibrosis, 15(3), 366-71. https://doi.org/10.1016/j.jcf.2015.05.008

Streptococcus pneumoniae oropharyngeal colonization in children and adolescents with cystic fibrosis. / Esposito, Susanna; Colombo, Carla; Tosco, Antonella; Montemitro, Enza; Volpi, Sonia; Ruggiero, Luca; Lelii, Mara; Bisogno, Arianna; Pelucchi, Claudio; Principi, Nicola; Italian Pneumococcal Study Group on Cystic Fibrosis.

In: Journal of Cystic Fibrosis, Vol. 15, No. 3, 05.2016, p. 366-71.

Research output: Contribution to journal › Article › peer-review

Esposito, S, Colombo, C, Tosco, A, Montemitro, E, Volpi, S, Ruggiero, L, Lelii, M, Bisogno, A, Pelucchi, C, Principi, N & Italian Pneumococcal Study Group on Cystic Fibrosis 2016, 'Streptococcus pneumoniae oropharyngeal colonization in children and adolescents with cystic fibrosis', Journal of Cystic Fibrosis, vol. 15, no. 3, pp. 366-71. https://doi.org/10.1016/j.jcf.2015.05.008

Esposito, Susanna ; Colombo, Carla ; Tosco, Antonella ; Montemitro, Enza ; Volpi, Sonia ; Ruggiero, Luca ; Lelii, Mara ; Bisogno, Arianna ; Pelucchi, Claudio ; Principi, Nicola ; Italian Pneumococcal Study Group on Cystic Fibrosis. / Streptococcus pneumoniae oropharyngeal colonization in children and adolescents with cystic fibrosis. In: Journal of Cystic Fibrosis. 2016 ; Vol. 15, No. 3. pp. 366-71.

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abstract = "BACKGROUND: This study was designed to evaluate Streptococcus pneumoniae (S. pneumoniae) carriage rates in patients with cystic fibrosis (CF).METHODS: An oropharyngeal swab was obtained from 212 CF children and adolescents enrolled during routine clinical visits. DNA from swabs was analyzed by real-time polymerase chain reaction.RESULTS: A total of 42 (19.8%) CF patients (mean age±standard deviation [SD], 12.0±3.3years) were colonized by S. pneumoniae. Carriage was more common in younger patients and tended to decline with age. Administration of systemic and/or inhaled antibiotics in the last 3months significantly correlated with a reduced carrier state [odds ratio (OR) 0.23, 95% confidence interval (CI) 0.07-0.69, and OR 0.26, 95% CI 0.08-0.77, respectively]. Vitamin D serum levels ≥30ng/mL were less common in carriers than that in non-carriers (OR 0.35; 95% CI 0.08-1.49). In both the vaccinated and unvaccinated subjects, serotypes 19F, 5, 4, and 9V were the most commonly carried serotypes.CONCLUSIONS: S. pneumoniae carrier state of school-age children and adolescents with CF is more prevalent than previously thought, and pneumococcal conjugate vaccination administered in the first year of life does not reduce the risk of re-colonization in later childhood and adolescence.",

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AU - Esposito, Susanna

AU - Colombo, Carla

AU - Tosco, Antonella

AU - Montemitro, Enza

AU - Volpi, Sonia

AU - Ruggiero, Luca

AU - Lelii, Mara

AU - Bisogno, Arianna

AU - Pelucchi, Claudio

AU - Principi, Nicola

AU - Italian Pneumococcal Study Group on Cystic Fibrosis

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N2 - BACKGROUND: This study was designed to evaluate Streptococcus pneumoniae (S. pneumoniae) carriage rates in patients with cystic fibrosis (CF).METHODS: An oropharyngeal swab was obtained from 212 CF children and adolescents enrolled during routine clinical visits. DNA from swabs was analyzed by real-time polymerase chain reaction.RESULTS: A total of 42 (19.8%) CF patients (mean age±standard deviation [SD], 12.0±3.3years) were colonized by S. pneumoniae. Carriage was more common in younger patients and tended to decline with age. Administration of systemic and/or inhaled antibiotics in the last 3months significantly correlated with a reduced carrier state [odds ratio (OR) 0.23, 95% confidence interval (CI) 0.07-0.69, and OR 0.26, 95% CI 0.08-0.77, respectively]. Vitamin D serum levels ≥30ng/mL were less common in carriers than that in non-carriers (OR 0.35; 95% CI 0.08-1.49). In both the vaccinated and unvaccinated subjects, serotypes 19F, 5, 4, and 9V were the most commonly carried serotypes.CONCLUSIONS: S. pneumoniae carrier state of school-age children and adolescents with CF is more prevalent than previously thought, and pneumococcal conjugate vaccination administered in the first year of life does not reduce the risk of re-colonization in later childhood and adolescence.

AB - BACKGROUND: This study was designed to evaluate Streptococcus pneumoniae (S. pneumoniae) carriage rates in patients with cystic fibrosis (CF).METHODS: An oropharyngeal swab was obtained from 212 CF children and adolescents enrolled during routine clinical visits. DNA from swabs was analyzed by real-time polymerase chain reaction.RESULTS: A total of 42 (19.8%) CF patients (mean age±standard deviation [SD], 12.0±3.3years) were colonized by S. pneumoniae. Carriage was more common in younger patients and tended to decline with age. Administration of systemic and/or inhaled antibiotics in the last 3months significantly correlated with a reduced carrier state [odds ratio (OR) 0.23, 95% confidence interval (CI) 0.07-0.69, and OR 0.26, 95% CI 0.08-0.77, respectively]. Vitamin D serum levels ≥30ng/mL were less common in carriers than that in non-carriers (OR 0.35; 95% CI 0.08-1.49). In both the vaccinated and unvaccinated subjects, serotypes 19F, 5, 4, and 9V were the most commonly carried serotypes.CONCLUSIONS: S. pneumoniae carrier state of school-age children and adolescents with CF is more prevalent than previously thought, and pneumococcal conjugate vaccination administered in the first year of life does not reduce the risk of re-colonization in later childhood and adolescence.

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