Abstract
BACKGROUND: This study was designed to evaluate Streptococcus pneumoniae (S. pneumoniae) carriage rates in patients with cystic fibrosis (CF).
METHODS: An oropharyngeal swab was obtained from 212 CF children and adolescents enrolled during routine clinical visits. DNA from swabs was analyzed by real-time polymerase chain reaction.
RESULTS: A total of 42 (19.8%) CF patients (mean age±standard deviation [SD], 12.0±3.3years) were colonized by S. pneumoniae. Carriage was more common in younger patients and tended to decline with age. Administration of systemic and/or inhaled antibiotics in the last 3months significantly correlated with a reduced carrier state [odds ratio (OR) 0.23, 95% confidence interval (CI) 0.07-0.69, and OR 0.26, 95% CI 0.08-0.77, respectively]. Vitamin D serum levels ≥30ng/mL were less common in carriers than that in non-carriers (OR 0.35; 95% CI 0.08-1.49). In both the vaccinated and unvaccinated subjects, serotypes 19F, 5, 4, and 9V were the most commonly carried serotypes.
CONCLUSIONS: S. pneumoniae carrier state of school-age children and adolescents with CF is more prevalent than previously thought, and pneumococcal conjugate vaccination administered in the first year of life does not reduce the risk of re-colonization in later childhood and adolescence.
| Original language | English |
|---|---|
| Pages (from-to) | 366-71 |
| Number of pages | 6 |
| Journal | Journal of Cystic Fibrosis |
| Volume | 15 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - May 2016 |
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Streptococcus pneumoniae oropharyngeal colonization in children and adolescents with cystic fibrosis. / Esposito, Susanna; Colombo, Carla; Tosco, Antonella; Montemitro, Enza; Volpi, Sonia; Ruggiero, Luca; Lelii, Mara; Bisogno, Arianna; Pelucchi, Claudio; Principi, Nicola; Italian Pneumococcal Study Group on Cystic Fibrosis.
In: Journal of Cystic Fibrosis, Vol. 15, No. 3, 05.2016, p. 366-71.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Streptococcus pneumoniae oropharyngeal colonization in children and adolescents with cystic fibrosis
AU - Esposito, Susanna
AU - Colombo, Carla
AU - Tosco, Antonella
AU - Montemitro, Enza
AU - Volpi, Sonia
AU - Ruggiero, Luca
AU - Lelii, Mara
AU - Bisogno, Arianna
AU - Pelucchi, Claudio
AU - Principi, Nicola
AU - Italian Pneumococcal Study Group on Cystic Fibrosis
N1 - Copyright © 2015. Published by Elsevier B.V.
PY - 2016/5
Y1 - 2016/5
N2 - BACKGROUND: This study was designed to evaluate Streptococcus pneumoniae (S. pneumoniae) carriage rates in patients with cystic fibrosis (CF).METHODS: An oropharyngeal swab was obtained from 212 CF children and adolescents enrolled during routine clinical visits. DNA from swabs was analyzed by real-time polymerase chain reaction.RESULTS: A total of 42 (19.8%) CF patients (mean age±standard deviation [SD], 12.0±3.3years) were colonized by S. pneumoniae. Carriage was more common in younger patients and tended to decline with age. Administration of systemic and/or inhaled antibiotics in the last 3months significantly correlated with a reduced carrier state [odds ratio (OR) 0.23, 95% confidence interval (CI) 0.07-0.69, and OR 0.26, 95% CI 0.08-0.77, respectively]. Vitamin D serum levels ≥30ng/mL were less common in carriers than that in non-carriers (OR 0.35; 95% CI 0.08-1.49). In both the vaccinated and unvaccinated subjects, serotypes 19F, 5, 4, and 9V were the most commonly carried serotypes.CONCLUSIONS: S. pneumoniae carrier state of school-age children and adolescents with CF is more prevalent than previously thought, and pneumococcal conjugate vaccination administered in the first year of life does not reduce the risk of re-colonization in later childhood and adolescence.
AB - BACKGROUND: This study was designed to evaluate Streptococcus pneumoniae (S. pneumoniae) carriage rates in patients with cystic fibrosis (CF).METHODS: An oropharyngeal swab was obtained from 212 CF children and adolescents enrolled during routine clinical visits. DNA from swabs was analyzed by real-time polymerase chain reaction.RESULTS: A total of 42 (19.8%) CF patients (mean age±standard deviation [SD], 12.0±3.3years) were colonized by S. pneumoniae. Carriage was more common in younger patients and tended to decline with age. Administration of systemic and/or inhaled antibiotics in the last 3months significantly correlated with a reduced carrier state [odds ratio (OR) 0.23, 95% confidence interval (CI) 0.07-0.69, and OR 0.26, 95% CI 0.08-0.77, respectively]. Vitamin D serum levels ≥30ng/mL were less common in carriers than that in non-carriers (OR 0.35; 95% CI 0.08-1.49). In both the vaccinated and unvaccinated subjects, serotypes 19F, 5, 4, and 9V were the most commonly carried serotypes.CONCLUSIONS: S. pneumoniae carrier state of school-age children and adolescents with CF is more prevalent than previously thought, and pneumococcal conjugate vaccination administered in the first year of life does not reduce the risk of re-colonization in later childhood and adolescence.
KW - Journal Article
U2 - 10.1016/j.jcf.2015.05.008
DO - 10.1016/j.jcf.2015.05.008
M3 - Article
VL - 15
SP - 366
EP - 371
JO - Journal of Cystic Fibrosis
JF - Journal of Cystic Fibrosis
SN - 1569-1993
IS - 3
ER -