Streptococcus pneumoniae pharyngeal colonization in school-age children and adolescents with cancer

Nicola Principi, V. Preti, Stefania Gaspari, Antonella Colombini, Marco Zecca, Leonardo Terranova, Maria Giuseppina Cefalo, V. Ierardi, Claudio Pelucchi, Susanna Esposito

Research output: Contribution to journalArticlepeer-review


Patients with cancer, particularly those with hematologic malignancies, are at an increased risk of invasive pneumococcal disease (IPD) and they are included in the list of subjects for whom pneumococcal vaccination is recommended. The main aim of this study was to evaluate Streptococcus pneumoniae colonization in school-aged children and adolescents with cancer to determine the potential protective efficacy of 13-valent pneumococcal conjugate vaccine (PCV13). An oropharyngeal swab was obtained from 277 patients (age range 6-17 years) with cancer during routine clinical visits and analyzed for S. pneumoniae using real-time polymerase chain reaction. S. pneumoniae was identified in 52 patients (18.8%), including 47/235 (20.0%) with hematologic malignancies and 5/42 (11.9%) with solid tumors. Colonization declined significantly with an increase in age (odds ratio [OR] 0.34, 95% confidence interval [CI] 0.16-0.71, and OR 0.30, 95% CI 0.11-0.82 in children aged 10-14 and ≥15 years, respectively, as compared to those

Original languageEnglish
Pages (from-to)301-307
Number of pages7
JournalHuman Vaccines and Immunotherapeutics
Issue number2
Publication statusPublished - Feb 1 2016


  • cancer
  • children
  • pediatrics
  • pneumococcal conjugate vaccine
  • pneumococcal infection
  • pneumococcal vaccine
  • Streptococcus pneumoniae
  • tumor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology


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