TY - JOUR
T1 - Streptococcus pneumoniae pharyngeal colonization in school-age children and adolescents with cancer
AU - Principi, Nicola
AU - Preti, V.
AU - Gaspari, Stefania
AU - Colombini, Antonella
AU - Zecca, Marco
AU - Terranova, Leonardo
AU - Cefalo, Maria Giuseppina
AU - Ierardi, V.
AU - Pelucchi, Claudio
AU - Esposito, Susanna
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Patients with cancer, particularly those with hematologic malignancies, are at an increased risk of invasive pneumococcal disease (IPD) and they are included in the list of subjects for whom pneumococcal vaccination is recommended. The main aim of this study was to evaluate Streptococcus pneumoniae colonization in school-aged children and adolescents with cancer to determine the potential protective efficacy of 13-valent pneumococcal conjugate vaccine (PCV13). An oropharyngeal swab was obtained from 277 patients (age range 6-17 years) with cancer during routine clinical visits and analyzed for S. pneumoniae using real-time polymerase chain reaction. S. pneumoniae was identified in 52 patients (18.8%), including 47/235 (20.0%) with hematologic malignancies and 5/42 (11.9%) with solid tumors. Colonization declined significantly with an increase in age (odds ratio [OR] 0.34, 95% confidence interval [CI] 0.16-0.71, and OR 0.30, 95% CI 0.11-0.82 in children aged 10-14 and ≥15 years, respectively, as compared to those
AB - Patients with cancer, particularly those with hematologic malignancies, are at an increased risk of invasive pneumococcal disease (IPD) and they are included in the list of subjects for whom pneumococcal vaccination is recommended. The main aim of this study was to evaluate Streptococcus pneumoniae colonization in school-aged children and adolescents with cancer to determine the potential protective efficacy of 13-valent pneumococcal conjugate vaccine (PCV13). An oropharyngeal swab was obtained from 277 patients (age range 6-17 years) with cancer during routine clinical visits and analyzed for S. pneumoniae using real-time polymerase chain reaction. S. pneumoniae was identified in 52 patients (18.8%), including 47/235 (20.0%) with hematologic malignancies and 5/42 (11.9%) with solid tumors. Colonization declined significantly with an increase in age (odds ratio [OR] 0.34, 95% confidence interval [CI] 0.16-0.71, and OR 0.30, 95% CI 0.11-0.82 in children aged 10-14 and ≥15 years, respectively, as compared to those
KW - cancer
KW - children
KW - pediatrics
KW - pneumococcal conjugate vaccine
KW - pneumococcal infection
KW - pneumococcal vaccine
KW - Streptococcus pneumoniae
KW - tumor
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U2 - 10.1080/21645515.2015.1090071
DO - 10.1080/21645515.2015.1090071
M3 - Article
VL - 12
SP - 301
EP - 307
JO - Human Vaccines and Immunotherapeutics
JF - Human Vaccines and Immunotherapeutics
SN - 2164-5515
IS - 2
ER -