Stress activation of limbic and cortical dopamine release is prevented by ICS 205-930 but not by diazepam

Assunta Imperato, Stefano Puglisi-Allegra, Alessandro Zocchi, Maria G. Scrocco, Paola Casolini, Luciano Angelucci

Research output: Contribution to journalArticle

Abstract

Systemic administration of the 5-HT3 receptor antagonist ICS 205-930, but not of the benzodiazepine diazepam, was able to prevent the stimulation of dopamine release in the nucleus accumbens and prefrontal cortex induced by restraint stress. These findings suggest that stress is not simply co-extensive with anxiety and that 5-HT3 receptors could regulate the dopaminergic response to stress.

Original languageEnglish
Pages (from-to)211-214
Number of pages4
JournalEuropean Journal of Pharmacology
Volume175
Issue number2
DOIs
Publication statusPublished - Jan 10 1990

Keywords

  • Diazepam
  • Dopamine release
  • ICS 205-930
  • Mesocortical dopamine system
  • Mesolimbic dopamine system
  • Stress

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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