Stress and nerve growth factor: Findings in animal models and humans

L. Aloe, E. Alleva, M. Fiore

Research output: Contribution to journalArticlepeer-review

Abstract

Stress is elicited by environmental, social or pathological conditions occurring during the life of animals and humans that determine changes in the nervous, endocrine and immune systems. In the present review, we present data supporting the hypothesis that stress-related events both in animal models and humans are characterized by modifications of endogenous nerve growth factor (NGF) synthesis and/or utilization. Stress inducing alteration in NGF synthesis and/or utilization appears to be more severe during neurogenesis and in early postnatal life. However, NGF endogenously released during stress may promote remodeling of damaged tissues following acute and/or chronic stressful events.

Original languageEnglish
Pages (from-to)159-166
Number of pages8
JournalPharmacology, Biochemistry and Behavior
Volume73
Issue number1
DOIs
Publication statusPublished - 2002

Keywords

  • Behavior
  • Electroconvulsive treatment
  • Environmental changes
  • Neurotrophin
  • NGF
  • Schizophrenia
  • Stress

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

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