Stress induced and sympathetically mediated electrocardiographic and circulatory variations in the primary hyperkinetic heart syndrome

M. Guazzi, C. Fiorentini, A. Polese, F. Magrini, M. T. Olivari

Research output: Contribution to journalArticlepeer-review

Abstract

As shown by the intropic changes, the sympathetic discharge on the heart is selectively enhanced by mental stimuli, and inhibited by pain in the primary hyperkinetic heart syndrome. In the steady state, the electrocardiogram shows flat, diphasic, or 'tucked' T waves. Mental stimulation or isoproterenol, and, respectively, pain or beta blockade induce changes of the repolarization phase divergent from steady state. The former causes ST depression and deep T wave inversion and the latter fully normalizes the repolarization phase. It is concluded that the electrical activity of the heart is directly influenced by the adrenergic drive in this disorder, and that different stressful factors can alter the repolarization phase in opposite ways in relation to the influence of the stimulus on the cardiac sympathetic tone.

Original languageEnglish
Pages (from-to)342-354
Number of pages13
JournalCardiovascular Research
Volume9
Issue number3
Publication statusPublished - 1975

ASJC Scopus subject areas

  • Physiology
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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