Stress-induced decrease of 3-methoxytyramine in the nucleus accumbens of the mouse is prevented by naltrexone pretreatment

Simona Cabib, Alberto Oliverio, Stefano Puglisi-Allegra

Research output: Contribution to journalArticle

Abstract

Pretreatment with naltrexone (2.5 and 5 mg/kg) prevented the decrease of 3-methoxytyramine (3-MT)/dopamine (DA) ratio induced by 2 h immobilization stress in the nucleus accumbens (NAS) of the mouse while it did not affect the stress-induced decrease of 3-MT/DA ratio in caudatus putamen (CP). Naltrexone also produced a slight antagonism of homovanillic acid (HVA)/DA ratio increase produced by stress in the frontal cortex (FC). These results point to an involvement of endogenous opioids in the effects of stress on DA metabolism in the mesolimbic system of the mouse.

Original languageEnglish
Pages (from-to)1031-1037
Number of pages7
JournalLife Sciences
Volume45
Issue number12
DOIs
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Pharmacology

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