Stress-induced hyperviscosity in the pathophysiology of takotsubo cardiomyopathy

Emanuele Cecchi, Guido Parodi, Cristina Giglioli, Silvia Passantino, Brunella Bandinelli, Agatina Alessandrello Liotta, Benedetta Bellandi, Gabriele Cioni, Maria Costanzo, Rosanna Abbate, Gian Franco Gensini, Davide Antoniucci, Lucia Mannini

Research output: Contribution to journalArticlepeer-review


Takotsubo cardiomyopathy (TC) is characterized by transient hypokinesis of the left ventricular apex or midventricular segments with coronary arteries without significant stenosis. It is often associated with emotional or physical stress; however, its pathophysiology is still unclear. In the present study, we analyzed the alterations in blood viscosity and markers of endothelial damage induced by sympathetic stimulation in patients with previous TC. Seventeen women (mean age 71 years) with previous TC, included and investigated in the TC Tuscany Registry, were compared to a control group of 8 age- and risk factor-matched women with chest pain and coronary arteries free of stenosis. All subjects underwent the cold pressor test (CPT). Before and after the CPT, the hemorheologic parameters (whole blood viscosity at 0.512 s-1 and 94.5 s-1, plasma viscosity, erythrocyte deformability index, and erythrocyte aggregation), catecholamines, plasminogen activator inhibitor-1 (PAI-1), and von Willebrand factor levels were assessed. The patients with TC had significantly greater baseline PAI-1 levels (p -1 (p

Original languageEnglish
Pages (from-to)1523-1529
Number of pages7
JournalThe American Journal of Cardiology
Issue number10
Publication statusPublished - May 15 2013

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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