Striatal D2 receptors changes parallel the progression of Parkinson's disease (PD)

G. Pizzolato, A. Cagnin, D. Delibori, F. Bracco, M. Dam, L. Battistin, F. Chierichetti, G. Ferlin

Research output: Contribution to journalArticle

Abstract

To investigate the relationship between D2 receptors changes and disease progression, we used 123I-IBZM SPET to longitudinally assess striatal D2 receptors activity in 13 PD patients who, at baseline study, were in the early drug-naive stage of the disease (mean H-Y score: 1.7±0.6). Follow-up SPET was performed after 3.1±1.3 y (mean H-Y score: 2.1±0.7; mean daily dosage of L-Dopa: 425±136mg). Caudate EBZM uptake at the baseline study showed a significant correlation with the ensuing rate of progression of PD, measured by the H-Y annual score change (r=-0.66, p

Original languageEnglish
Pages (from-to)20
Number of pages1
JournalItalian Journal of Neurological Sciences
Volume18
Issue number4
Publication statusPublished - 1997

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Corpus Striatum
Levodopa
Parkinson Disease
Disease Progression
Pharmaceutical Preparations
3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide
Parkinson Disease 13

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Pizzolato, G., Cagnin, A., Delibori, D., Bracco, F., Dam, M., Battistin, L., ... Ferlin, G. (1997). Striatal D2 receptors changes parallel the progression of Parkinson's disease (PD). Italian Journal of Neurological Sciences, 18(4), 20.

Striatal D2 receptors changes parallel the progression of Parkinson's disease (PD). / Pizzolato, G.; Cagnin, A.; Delibori, D.; Bracco, F.; Dam, M.; Battistin, L.; Chierichetti, F.; Ferlin, G.

In: Italian Journal of Neurological Sciences, Vol. 18, No. 4, 1997, p. 20.

Research output: Contribution to journalArticle

Pizzolato, G, Cagnin, A, Delibori, D, Bracco, F, Dam, M, Battistin, L, Chierichetti, F & Ferlin, G 1997, 'Striatal D2 receptors changes parallel the progression of Parkinson's disease (PD)', Italian Journal of Neurological Sciences, vol. 18, no. 4, pp. 20.
Pizzolato G, Cagnin A, Delibori D, Bracco F, Dam M, Battistin L et al. Striatal D2 receptors changes parallel the progression of Parkinson's disease (PD). Italian Journal of Neurological Sciences. 1997;18(4):20.
Pizzolato, G. ; Cagnin, A. ; Delibori, D. ; Bracco, F. ; Dam, M. ; Battistin, L. ; Chierichetti, F. ; Ferlin, G. / Striatal D2 receptors changes parallel the progression of Parkinson's disease (PD). In: Italian Journal of Neurological Sciences. 1997 ; Vol. 18, No. 4. pp. 20.
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