Abstract
To investigate the relationship between D2 receptors changes and disease progression, we used 123I-IBZM SPET to longitudinally assess striatal D2 receptors activity in 13 PD patients who, at baseline study, were in the early drug-naive stage of the disease (mean H-Y score: 1.7±0.6). Follow-up SPET was performed after 3.1±1.3 y (mean H-Y score: 2.1±0.7; mean daily dosage of L-Dopa: 425±136mg). Caudate EBZM uptake at the baseline study showed a significant correlation with the ensuing rate of progression of PD, measured by the H-Y annual score change (r=-0.66, p
Original language | English |
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Pages (from-to) | 20 |
Number of pages | 1 |
Journal | Italian Journal of Neurological Sciences |
Volume | 18 |
Issue number | 4 |
Publication status | Published - 1997 |
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Neurology