Striatal D2 receptors changes parallel the progression of Parkinson's disease (PD)

G. Pizzolato, A. Cagnin, D. Delibori, F. Bracco, M. Dam, L. Battistin, F. Chierichetti, G. Ferlin

Research output: Contribution to journalArticlepeer-review

Abstract

To investigate the relationship between D2 receptors changes and disease progression, we used 123I-IBZM SPET to longitudinally assess striatal D2 receptors activity in 13 PD patients who, at baseline study, were in the early drug-naive stage of the disease (mean H-Y score: 1.7±0.6). Follow-up SPET was performed after 3.1±1.3 y (mean H-Y score: 2.1±0.7; mean daily dosage of L-Dopa: 425±136mg). Caudate EBZM uptake at the baseline study showed a significant correlation with the ensuing rate of progression of PD, measured by the H-Y annual score change (r=-0.66, p

Original languageEnglish
Pages (from-to)20
Number of pages1
JournalItalian Journal of Neurological Sciences
Volume18
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Striatal D2 receptors changes parallel the progression of Parkinson's disease (PD)'. Together they form a unique fingerprint.

Cite this