Striatal dopamine D2 receptors in patients with narcolepsy measured with PET and 11C-racloprid

N. Kham, A. Antonini, D. Parkes, M. J. Dahlitz, K. Meier-Ewert, A. Weindl, K. L. Leenders

Research output: Contribution to journalArticle

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Abstract

We investigated in vivo D2 receptor binding using 11C-raclopride and PET in the striatum of 17 subjects with the narcoleptic syndrome. Putamen and caudate nucleus 11C-raclopride uptake was comparable in the total patient group and controls, and the tracer uptake was similar in the HLA-DR2-positive (n = 12) and HLA-DR2-negative (n = 5) narcoleptic subjects. There was a significant increase in 11C-raclopride uptake in the putamen of narcoleptic subjects older than 31 years (n = 11) when compared with age-matched controls (n = 15). There was no evidence of involvement of the striatal D2 dopaminergic neurotransmitter system in the basic pathophysiology of the narcoleptic syndrome despite an age-related increase in putaminal 11C-raclopride uptake.

Original languageEnglish
Pages (from-to)2101-2104
Number of pages4
JournalNeurology
Volume44
Issue number11
Publication statusPublished - 1994

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Raclopride
Corpus Striatum
Narcolepsy
Dopamine D2 Receptors
HLA-DR2 Antigen
Putamen
Caudate Nucleus
Neurotransmitter Agents
Control Groups
Dopamine
Syndrome
Striatum
Nucleus

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

Cite this

Kham, N., Antonini, A., Parkes, D., Dahlitz, M. J., Meier-Ewert, K., Weindl, A., & Leenders, K. L. (1994). Striatal dopamine D2 receptors in patients with narcolepsy measured with PET and 11C-racloprid. Neurology, 44(11), 2101-2104.

Striatal dopamine D2 receptors in patients with narcolepsy measured with PET and 11C-racloprid. / Kham, N.; Antonini, A.; Parkes, D.; Dahlitz, M. J.; Meier-Ewert, K.; Weindl, A.; Leenders, K. L.

In: Neurology, Vol. 44, No. 11, 1994, p. 2101-2104.

Research output: Contribution to journalArticle

Kham, N, Antonini, A, Parkes, D, Dahlitz, MJ, Meier-Ewert, K, Weindl, A & Leenders, KL 1994, 'Striatal dopamine D2 receptors in patients with narcolepsy measured with PET and 11C-racloprid', Neurology, vol. 44, no. 11, pp. 2101-2104.
Kham N, Antonini A, Parkes D, Dahlitz MJ, Meier-Ewert K, Weindl A et al. Striatal dopamine D2 receptors in patients with narcolepsy measured with PET and 11C-racloprid. Neurology. 1994;44(11):2101-2104.
Kham, N. ; Antonini, A. ; Parkes, D. ; Dahlitz, M. J. ; Meier-Ewert, K. ; Weindl, A. ; Leenders, K. L. / Striatal dopamine D2 receptors in patients with narcolepsy measured with PET and 11C-racloprid. In: Neurology. 1994 ; Vol. 44, No. 11. pp. 2101-2104.
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