Striatal dopamine D2 receptors in patients with narcolepsy measured with PET and 11C-racloprid

N. Kham, A. Antonini, D. Parkes, M. J. Dahlitz, K. Meier-Ewert, A. Weindl, K. L. Leenders

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated in vivo D2 receptor binding using 11C-raclopride and PET in the striatum of 17 subjects with the narcoleptic syndrome. Putamen and caudate nucleus 11C-raclopride uptake was comparable in the total patient group and controls, and the tracer uptake was similar in the HLA-DR2-positive (n = 12) and HLA-DR2-negative (n = 5) narcoleptic subjects. There was a significant increase in 11C-raclopride uptake in the putamen of narcoleptic subjects older than 31 years (n = 11) when compared with age-matched controls (n = 15). There was no evidence of involvement of the striatal D2 dopaminergic neurotransmitter system in the basic pathophysiology of the narcoleptic syndrome despite an age-related increase in putaminal 11C-raclopride uptake.

Original languageEnglish
Pages (from-to)2101-2104
Number of pages4
JournalNeurology
Volume44
Issue number11
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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