Abstract
We measured striatal dopamine transporter binding using [ 123I]ioflupane and SPECT in patients with Parkinson's disease associated with the LRRK2 (PARK8) Gly2019Ser gene mutation (LRRK2-PD) and in gene-negative patients with idiopathic Parkinson's disease (IPD) of comparable disease duration and severity. The LRRK2-PD group consisted of a total of 10 patients (3 sporadic) with mean age 62 ± 14 years, disease duration 9 ± 3 years, and UPDRS III motor score 21.60 ± 6.65. The control IPD group consisted of 15 patients with mean age 59 ± 9 years, disease duration 9 ± 5 years, and UPDRS III motor score 23.80 ± 8.69. [ 123I]ioflupane-specific uptake ratios were calculated for caudate nucleus and putamen using the occipital cortex as reference region. We found no differences between the LRRK2-PD group and IPD in all items studied. In particular, putamen and caudate uptake values as well as side asymmetry indexes and putamen/caudate ratios all revealed comparable between-group values. We conclude that in these patients carrying the LRRK2 Gly2019Ser mutation, the neurodegenerative process results in a pattern of nigrostriatal do-paminergic dysfunction similar to that observed in IPD.
Original language | English |
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Pages (from-to) | 1144-1147 |
Number of pages | 4 |
Journal | Movement Disorders |
Volume | 21 |
Issue number | 8 |
DOIs | |
Publication status | Published - Aug 2006 |
Keywords
- [ I]ioflupane SPECT
- Gly2019Ser mutation
- LRRK2
- PARK8
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)