Striatal dopamine transporter binding in Parkinson's disease associated with the LRRK2 Gly2019Ser mutation

Ioannis U. Isaias, Riccardo Benti, Stefano Goldwurn, Michela Zini, Roberto Cilia, Paolo Gerundini, Alessio Di Fonzo, Vincenzo Bonifati, Gianni Pezzoli, Angelo Antonini

Research output: Contribution to journalArticlepeer-review

Abstract

We measured striatal dopamine transporter binding using [ 123I]ioflupane and SPECT in patients with Parkinson's disease associated with the LRRK2 (PARK8) Gly2019Ser gene mutation (LRRK2-PD) and in gene-negative patients with idiopathic Parkinson's disease (IPD) of comparable disease duration and severity. The LRRK2-PD group consisted of a total of 10 patients (3 sporadic) with mean age 62 ± 14 years, disease duration 9 ± 3 years, and UPDRS III motor score 21.60 ± 6.65. The control IPD group consisted of 15 patients with mean age 59 ± 9 years, disease duration 9 ± 5 years, and UPDRS III motor score 23.80 ± 8.69. [ 123I]ioflupane-specific uptake ratios were calculated for caudate nucleus and putamen using the occipital cortex as reference region. We found no differences between the LRRK2-PD group and IPD in all items studied. In particular, putamen and caudate uptake values as well as side asymmetry indexes and putamen/caudate ratios all revealed comparable between-group values. We conclude that in these patients carrying the LRRK2 Gly2019Ser mutation, the neurodegenerative process results in a pattern of nigrostriatal do-paminergic dysfunction similar to that observed in IPD.

Original languageEnglish
Pages (from-to)1144-1147
Number of pages4
JournalMovement Disorders
Volume21
Issue number8
DOIs
Publication statusPublished - Aug 2006

Keywords

  • [ I]ioflupane SPECT
  • Gly2019Ser mutation
  • LRRK2
  • PARK8

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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