Striatal dopamine transporter binding in patients with Parkinson's disease and severe occupational hydrocarbon exposure

M. Canesi; R. Benti; G. Marotta; R. Cilia; I. U. Isaias; P. Gerundini; G. Pezzoli; A. Antonini

doi:10.1111/j.1468-1331.2006.01642.x

Striatal dopamine transporter binding in patients with Parkinson's disease and severe occupational hydrocarbon exposure

M. Canesi, R. Benti, G. Marotta, R. Cilia, I. U. Isaias, P. Gerundini, G. Pezzoli, A. Antonini

Research output: Contribution to journal › Article › peer-review

Abstract

We used ¹²³I-Ioflupane SPECT to study striatal dopamine transporter (DAT) binding in 36 Parkinson's disease (PD) patients with history of severe occupational exposure to hydrocarbons. Data were compared with 38 PD patients without exposure history as well as healthy controls. Both PD cohorts showed significant striatal uptake decrements compared with controls. We found significantly lower values in the whole striatum of exposed compared with non-exposed patients (0.83 ± 0.25 vs. 1.05 ± 0.39; P = 0.004), more pronounced in the putamen (0.61 ± 0.24 vs. 0.85 ± 0.42; P = 0.004). We conclude that severe occupational exposure to hydrocarbons may modify disease course and ultimately accelerate nigro-striatal denervation.

Original language	English
Pages (from-to)	297-299
Number of pages	3
Journal	European Journal of Neurology
Volume	14
Issue number	3
DOIs	https://doi.org/10.1111/j.1468-1331.2006.01642.x
Publication status	Published - Mar 2007

Keywords

I-Ioflupane
Exposure
Hydrocarbons
Occupation
Parkinson's disease
SPECT

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)

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title = "Striatal dopamine transporter binding in patients with Parkinson's disease and severe occupational hydrocarbon exposure",

abstract = "We used 123I-Ioflupane SPECT to study striatal dopamine transporter (DAT) binding in 36 Parkinson's disease (PD) patients with history of severe occupational exposure to hydrocarbons. Data were compared with 38 PD patients without exposure history as well as healthy controls. Both PD cohorts showed significant striatal uptake decrements compared with controls. We found significantly lower values in the whole striatum of exposed compared with non-exposed patients (0.83 ± 0.25 vs. 1.05 ± 0.39; P = 0.004), more pronounced in the putamen (0.61 ± 0.24 vs. 0.85 ± 0.42; P = 0.004). We conclude that severe occupational exposure to hydrocarbons may modify disease course and ultimately accelerate nigro-striatal denervation.",

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AU - Canesi, M.

AU - Benti, R.

AU - Marotta, G.

AU - Cilia, R.

AU - Isaias, I. U.

AU - Gerundini, P.

AU - Pezzoli, G.

AU - Antonini, A.

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