Striatal dopamine transporter SPECT quantification: head-to-head comparison between two three-dimensional automatic tools

Silvia Morbelli, Dario Arnaldi, Eugenia Cella, Stefano Raffa, Maria Isabella Donegani, Selene Capitanio, Federico Massa, Alberto Miceli, Laura Filippi, Andrea Chincarini, Flavio Nobili

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Our aim was to compare a widely distributed commercial tool with an older free software (i) one another, (ii) with a clinical motor score, (iii) versus reading by experts. Procedures: We analyzed consecutive scans from one-hundred and fifty-one outpatients submitted to brain DAT SPECT for a suspected parkinsonism. Images were post-processed using a commercial (Datquant®) and a free (BasGanV2) software. Reading by expert was the gold standard. A subset of patients with pathological or borderline scan was evaluated with the clinical Unified Parkinson’s Disease Rating Scale, motor part (MDS-UPDRS-III). Results: SBR, putamen-to-caudate (P/C) ratio, and both P and C asymmetries were highly correlated between the two software with Pearson’s ‘r’ correlation coefficients ranging from.706 to.887. Correlation coefficients with the MDS-UPDRS III score were higher with caudate than with putamen SBR values with both software, and in general higher with BasGanV2 than with Datquant®. Datquant® correspondence with expert reading was 84.1% (94.0% by additionally considering the P/C ratio as a further index). BasGanV2 correspondence with expert reading was 80.8% (86.1% by additionally considering the P/C ratio). Conclusions: Both Datquant® and BasGanV2 work reasonably well and similarly one another in semi-quantification of DAT SPECT. Both tools have their own strength and pitfalls that must be known in detail by users in order to obtain the best help in visual reading and reporting of DAT SPECT.

Original languageEnglish
Article number137
JournalEJNMMI Research
Volume10
Issue number1
DOIs
Publication statusPublished - 2020

Keywords

  • BasGanV2
  • Datquant®
  • Dopamine transporter
  • Parkinson
  • Semi-quantification
  • SPECT

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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