Abstract
Introduction: The neuroanatomical substrate of stridor associated with Multiple System Atrophy (MSA) remains unclear. We evaluated stridor-related gray matter (GM) changes in MSA. Methods: 36 MSA patients underwent standardized nocturnal video-polysomnography and brain MRI. Differences in GM density between MSA patients with and without stridor and a sample of 22 matched healthy controls were evaluated with Voxel Based Morphometry protocol supplemented by a specific tool (SUIT) for analysing infratentorial structures. Results: Stridor was confirmed in 14 patients (10 MSA-cerebellar variant; 10 M; mean ± SD age = 61.6 ± 8.9years; disease duration = 5.2 ± 2.9years) and absent in 22 (11 MSA-cerebellar variant; 18 M; age = 61.4 ± 9.9years; disease duration = 4.8 ± 3.4years). Compared to MSA without stridor, patients with stridor showed higher GM density in the cerebellum (p < 0.05, corrected for the MSA-cerebellar variant and uncorrected when considering both MSA-variants) and lower in the striatum (p < 0.05, uncorrected). Conclusions: This preliminary study has demonstrated for the first time in MSA stridor-related GM changes in striatal and cerebellar regions. Abnormalities in these regions were previously reported in dystonic disorders affecting laryngeal muscles, suggesting the hypothesis that stridor pathophysiology is dystonia-related. These results need however to be confirmed in a larger sample of patients.
| Original language | English |
|---|---|
| Pages (from-to) | 226-230 |
| Number of pages | 5 |
| Journal | Parkinsonism and Related Disorders |
| Volume | 62 |
| DOIs | |
| Publication status | Published - May 1 2019 |
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Keywords
- Multiple system atrophy
- Stridor
- Voxel based morphometry
ASJC Scopus subject areas
- Neurology
- Geriatrics and Gerontology
- Clinical Neurology
Cite this
Stridor-related gray matter alterations in multiple system atrophy : A pilot study. / Testa, Claudia; Calandra-Buonaura, Giovanna; Evangelisti, Stefania; Giannini, Giulia; Provini, Federica; Ratti, Stefano; Cecere, Annagrazia; Talozzi, Lia; Manners, David Neil; Lodi, Raffaele; Tonon, Caterina; Cortelli, Pietro.
In: Parkinsonism and Related Disorders, Vol. 62, 01.05.2019, p. 226-230.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Stridor-related gray matter alterations in multiple system atrophy
T2 - A pilot study
AU - Testa, Claudia
AU - Calandra-Buonaura, Giovanna
AU - Evangelisti, Stefania
AU - Giannini, Giulia
AU - Provini, Federica
AU - Ratti, Stefano
AU - Cecere, Annagrazia
AU - Talozzi, Lia
AU - Manners, David Neil
AU - Lodi, Raffaele
AU - Tonon, Caterina
AU - Cortelli, Pietro
N1 - Ricercatori distaccati presso IRCCS a seguito Convenzione esclusiva con Università di Bologna (Calandra-Buonaura Giovanna, Provini Federica, Lodi Raffaele, Tonon Caterina,Cortelli Pietro)
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Introduction: The neuroanatomical substrate of stridor associated with Multiple System Atrophy (MSA) remains unclear. We evaluated stridor-related gray matter (GM) changes in MSA. Methods: 36 MSA patients underwent standardized nocturnal video-polysomnography and brain MRI. Differences in GM density between MSA patients with and without stridor and a sample of 22 matched healthy controls were evaluated with Voxel Based Morphometry protocol supplemented by a specific tool (SUIT) for analysing infratentorial structures. Results: Stridor was confirmed in 14 patients (10 MSA-cerebellar variant; 10 M; mean ± SD age = 61.6 ± 8.9years; disease duration = 5.2 ± 2.9years) and absent in 22 (11 MSA-cerebellar variant; 18 M; age = 61.4 ± 9.9years; disease duration = 4.8 ± 3.4years). Compared to MSA without stridor, patients with stridor showed higher GM density in the cerebellum (p < 0.05, corrected for the MSA-cerebellar variant and uncorrected when considering both MSA-variants) and lower in the striatum (p < 0.05, uncorrected). Conclusions: This preliminary study has demonstrated for the first time in MSA stridor-related GM changes in striatal and cerebellar regions. Abnormalities in these regions were previously reported in dystonic disorders affecting laryngeal muscles, suggesting the hypothesis that stridor pathophysiology is dystonia-related. These results need however to be confirmed in a larger sample of patients.
AB - Introduction: The neuroanatomical substrate of stridor associated with Multiple System Atrophy (MSA) remains unclear. We evaluated stridor-related gray matter (GM) changes in MSA. Methods: 36 MSA patients underwent standardized nocturnal video-polysomnography and brain MRI. Differences in GM density between MSA patients with and without stridor and a sample of 22 matched healthy controls were evaluated with Voxel Based Morphometry protocol supplemented by a specific tool (SUIT) for analysing infratentorial structures. Results: Stridor was confirmed in 14 patients (10 MSA-cerebellar variant; 10 M; mean ± SD age = 61.6 ± 8.9years; disease duration = 5.2 ± 2.9years) and absent in 22 (11 MSA-cerebellar variant; 18 M; age = 61.4 ± 9.9years; disease duration = 4.8 ± 3.4years). Compared to MSA without stridor, patients with stridor showed higher GM density in the cerebellum (p < 0.05, corrected for the MSA-cerebellar variant and uncorrected when considering both MSA-variants) and lower in the striatum (p < 0.05, uncorrected). Conclusions: This preliminary study has demonstrated for the first time in MSA stridor-related GM changes in striatal and cerebellar regions. Abnormalities in these regions were previously reported in dystonic disorders affecting laryngeal muscles, suggesting the hypothesis that stridor pathophysiology is dystonia-related. These results need however to be confirmed in a larger sample of patients.
KW - Multiple system atrophy
KW - Stridor
KW - Voxel based morphometry
UR - http://www.scopus.com/inward/record.url?scp=85057500024&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85057500024&partnerID=8YFLogxK
U2 - 10.1016/j.parkreldis.2018.11.018
DO - 10.1016/j.parkreldis.2018.11.018
M3 - Article
C2 - 30509725
AN - SCOPUS:85057500024
VL - 62
SP - 226
EP - 230
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
SN - 1353-8020
ER -