Stroke due to typical thrombotic thrombocytopenic purpura treated successfully with intravenous thrombolysis and therapeutic plasma exchange

Matteo Boattini, Gaetano Procaccianti

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6 Citations (Scopus)

Abstract

We report a case of a 39-year-old man with expressive aphasia due to occlusion of the temporal stem of the left middle cerebral artery. Laboratory tests showed microangiopathic haemolytic anaemia and thrombocytopenia. A thrombotic thrombocytopenic purpura (TTP) was diagnosed, and thrombolytic therapy (TT) with alteplase followed by therapeutic plasma exchange (TPE) were performed with complete resolution of symptoms. The gold standard TTP treatment is TPE, and its delay can be lethal. The use of TT in TTP is controversial and has potential risks. This case shows a successful TT in a patient with typical TTP presenting as a stroke due to a large cerebral artery occlusion.

Original languageEnglish
Article number008426
JournalBMJ Case Reports
DOIs
Publication statusPublished - 2013

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Thrombotic Thrombocytopenic Purpura
Plasma Exchange
Thrombolytic Therapy
Stroke
Broca Aphasia
Cerebral Arteries
Hemolytic Anemia
Middle Cerebral Artery
Tissue Plasminogen Activator
Thrombocytopenia
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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