Stroke in first-degree relatives of patients with cervical artery dissection

M. Kloss, C. Grond-Ginsbach, A. Pezzini, T. M. Metso, A. J. Metso, S. Debette, D. Leys, J. Dallongeville, V. Caso, V. Thijs, A. Bersano, E. Touzé, L. H. Bonati, T. Tatlisumak, M. L. Arnold, P. A. Lyrer, S. T. Engelter, Massimo Pandolfo, Marie Bodenant, Fabien LouilletJean Louis Mas, Sandrine Deltour, Léger Anne Léger, Sandrine Canaple, Olivier Godefroy, Béjot Yannick Béjot, Thierry Moulin, Fabrice Vuillier, Michael Dos Santos, Rainer Malik, Ingrid Hausser, Tobias Brandt, Constanze Thomas-Feles, Ralf Weber, Alessia Giossi, Irene Volonghi, Alessandro Padovani, Silvia Lanfranconi, Pierluigi Baron, Carlo Ferrarese, Giacomo Giacolone, Stefano Paolucci, Felix Fluri, Florian Hatz, Dominique Gisler, Margareth Amort, Steve Bevan, Ayse Altintas

Research output: Contribution to journalArticlepeer-review


Background and purpose: Patients with ischaemic stroke (IS) caused by a spontaneous cervical artery dissection (CeAD) worry about an increased risk for stroke in their families. The occurrence of stroke in relatives of patients with CeAD and in those with ischaemic stroke attributable to other (non-CeAD) causes were compared. Methods: The frequency of stroke in first-degree relatives (family history of stroke, FHS) was studied in IS patients (CeAD patients and age- and sex-matched non-CeAD patients) from the Cervical Artery Dissection and Ischemic Stroke Patients (CADISP) database. FHS ≤ 50 and FHS > 50 were defined as having relatives who suffered stroke at the age of ≤50 or >50 years. FHS ≤ 50 and FHS > 50 were studied in CeAD and non-CeAD IS patients and related to age, sex, number of siblings, hypertension, hypercholesterolemia, smoking and body mass index (BMI). Results: In all, 1225 patients were analyzed. FHS ≤ 50 was less frequent in CeAD patients (15/598 = 2.5%) than in non-CeAD IS patients (38/627 = 6.1%) (P = 0.003; odds ratio 0.40, 95% confidence interval 0.22-0.73), also after adjustment for age, sex and number of siblings (P = 0.005; odds ratio 0.42, 95% confidence interval 0.23-0.77). The frequency of FHS > 50 was similar in both study groups. Vascular risk factors did not differ between patients with positive or negative FHS ≤ 50. However, patients with FHS > 50 were more likely to have hypertension and higher BMI. Conclusion: Relatives of CeAD patients had fewer strokes at a young age than relatives of non-CeAD IS stroke patients.

Original languageEnglish
Pages (from-to)1102-1107
Number of pages6
JournalEuropean Journal of Neurology
Issue number8
Publication statusPublished - 2014


  • Cervical artery dissection (CeAD)
  • Family history of stroke (FHS)
  • Young stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)


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