Stroke prevention

Recent achievements and new challenges

Michael J. Katsnelson, David Della-Morte, Ralph L. Sacco, Tatjana Rundek

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Stroke remains a major health problem despite the great efforts made worldwide to fight against it. Despite therapeutic achievements to treat ischemic stroke patients in stroke units with tissue plasminogen activator (tPA), prevention remains the most powerful strategy to cure this complex disease. Stroke is a heterogeneous and multi-factorial disease caused by the combination of vascular risk factors, environment, and genetic factors. These risk factors can be subdivided into non-modifiable (age, sex, race-ethnicity, genetic variations and predispositions) and modifiable (hypertension, diabetes, dyslipidemia, atrial fibrillation, carotid artery stenosis, smoking, poor diet, physical inactivity and obesity). The metabolic syndrome, a cluster of metabolic risk factors within an individual, has been recognized as and important factor associated with an increased risk of stroke. Recently, a great emphasis has been given to the investigations of genetic factors and stroke risk, which may lead to the discovery of new biomarkers for prevention, diagnosis and to the alternative strategies for stroke treatment. In this review we sought to discuss the main risk factors for stroke and the current strategies of stroke prevention.

Original languageEnglish
Pages (from-to)409-419
Number of pages11
JournalPeriodicum Biologorum
Volume114
Issue number3
Publication statusPublished - 2012

Fingerprint

stroke
Stroke
risk factors
Medical problems
Biomarkers
Tissue Plasminogen Activator
Nutrition
t-plasminogen activator
carotid arteries
Carotid Stenosis
smoking (food products)
metabolic syndrome
hyperlipidemia
Genetic Predisposition to Disease
Dyslipidemias
nationalities and ethnic groups
blood vessels
Atrial Fibrillation
hypertension
diabetes

Keywords

  • Genetics
  • Ischemic stroke
  • Metabolic syndrome
  • Prevention
  • Risk factors

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Katsnelson, M. J., Della-Morte, D., Sacco, R. L., & Rundek, T. (2012). Stroke prevention: Recent achievements and new challenges. Periodicum Biologorum, 114(3), 409-419.

Stroke prevention : Recent achievements and new challenges. / Katsnelson, Michael J.; Della-Morte, David; Sacco, Ralph L.; Rundek, Tatjana.

In: Periodicum Biologorum, Vol. 114, No. 3, 2012, p. 409-419.

Research output: Contribution to journalArticle

Katsnelson, MJ, Della-Morte, D, Sacco, RL & Rundek, T 2012, 'Stroke prevention: Recent achievements and new challenges', Periodicum Biologorum, vol. 114, no. 3, pp. 409-419.
Katsnelson, Michael J. ; Della-Morte, David ; Sacco, Ralph L. ; Rundek, Tatjana. / Stroke prevention : Recent achievements and new challenges. In: Periodicum Biologorum. 2012 ; Vol. 114, No. 3. pp. 409-419.
@article{2c0cc06da56b4d5f8b561f0b5500c19c,
title = "Stroke prevention: Recent achievements and new challenges",
abstract = "Stroke remains a major health problem despite the great efforts made worldwide to fight against it. Despite therapeutic achievements to treat ischemic stroke patients in stroke units with tissue plasminogen activator (tPA), prevention remains the most powerful strategy to cure this complex disease. Stroke is a heterogeneous and multi-factorial disease caused by the combination of vascular risk factors, environment, and genetic factors. These risk factors can be subdivided into non-modifiable (age, sex, race-ethnicity, genetic variations and predispositions) and modifiable (hypertension, diabetes, dyslipidemia, atrial fibrillation, carotid artery stenosis, smoking, poor diet, physical inactivity and obesity). The metabolic syndrome, a cluster of metabolic risk factors within an individual, has been recognized as and important factor associated with an increased risk of stroke. Recently, a great emphasis has been given to the investigations of genetic factors and stroke risk, which may lead to the discovery of new biomarkers for prevention, diagnosis and to the alternative strategies for stroke treatment. In this review we sought to discuss the main risk factors for stroke and the current strategies of stroke prevention.",
keywords = "Genetics, Ischemic stroke, Metabolic syndrome, Prevention, Risk factors",
author = "Katsnelson, {Michael J.} and David Della-Morte and Sacco, {Ralph L.} and Tatjana Rundek",
year = "2012",
language = "English",
volume = "114",
pages = "409--419",
journal = "Periodicum Biologorum",
issn = "0031-5362",
publisher = "Croatian Society of Natural Sciences",
number = "3",

}

TY - JOUR

T1 - Stroke prevention

T2 - Recent achievements and new challenges

AU - Katsnelson, Michael J.

AU - Della-Morte, David

AU - Sacco, Ralph L.

AU - Rundek, Tatjana

PY - 2012

Y1 - 2012

N2 - Stroke remains a major health problem despite the great efforts made worldwide to fight against it. Despite therapeutic achievements to treat ischemic stroke patients in stroke units with tissue plasminogen activator (tPA), prevention remains the most powerful strategy to cure this complex disease. Stroke is a heterogeneous and multi-factorial disease caused by the combination of vascular risk factors, environment, and genetic factors. These risk factors can be subdivided into non-modifiable (age, sex, race-ethnicity, genetic variations and predispositions) and modifiable (hypertension, diabetes, dyslipidemia, atrial fibrillation, carotid artery stenosis, smoking, poor diet, physical inactivity and obesity). The metabolic syndrome, a cluster of metabolic risk factors within an individual, has been recognized as and important factor associated with an increased risk of stroke. Recently, a great emphasis has been given to the investigations of genetic factors and stroke risk, which may lead to the discovery of new biomarkers for prevention, diagnosis and to the alternative strategies for stroke treatment. In this review we sought to discuss the main risk factors for stroke and the current strategies of stroke prevention.

AB - Stroke remains a major health problem despite the great efforts made worldwide to fight against it. Despite therapeutic achievements to treat ischemic stroke patients in stroke units with tissue plasminogen activator (tPA), prevention remains the most powerful strategy to cure this complex disease. Stroke is a heterogeneous and multi-factorial disease caused by the combination of vascular risk factors, environment, and genetic factors. These risk factors can be subdivided into non-modifiable (age, sex, race-ethnicity, genetic variations and predispositions) and modifiable (hypertension, diabetes, dyslipidemia, atrial fibrillation, carotid artery stenosis, smoking, poor diet, physical inactivity and obesity). The metabolic syndrome, a cluster of metabolic risk factors within an individual, has been recognized as and important factor associated with an increased risk of stroke. Recently, a great emphasis has been given to the investigations of genetic factors and stroke risk, which may lead to the discovery of new biomarkers for prevention, diagnosis and to the alternative strategies for stroke treatment. In this review we sought to discuss the main risk factors for stroke and the current strategies of stroke prevention.

KW - Genetics

KW - Ischemic stroke

KW - Metabolic syndrome

KW - Prevention

KW - Risk factors

UR - http://www.scopus.com/inward/record.url?scp=84873617252&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873617252&partnerID=8YFLogxK

M3 - Article

VL - 114

SP - 409

EP - 419

JO - Periodicum Biologorum

JF - Periodicum Biologorum

SN - 0031-5362

IS - 3

ER -