Stromal cells in primary myelofibrosis: ultrastructural observations

Grazieila Biagini, Bruno Severi, Edmondo Govoni, Paola Preda, Stefano Pileri, Giuseppe Martinelli, Giuseppe Visani, Carlo Finelli, Carla Castaldini

Research output: Contribution to journalArticlepeer-review


The bone marrows of five patients with primary myelofibrosis at different stages of the disease have been studied. In the myelofibrotic bone marrow, associated with "reticulum cells", two other cell types have been identified, namely fibroblast-like and myofibroblast-like reticulum cells, as well as a spectrum of transitional forms. Our findings suggest that reticulum cells may represent a reserve stromal cell pool (i.e. primitive reticulum cells) able to modulate themselves and to transform differently according to functional requirements. Some suggestions regarding the functional significance of fibroblastlike and myofibroblast-like reticulum cells in primary myelofibrosis are suggested.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalVirchows Archiv B Cell Pathology Including Molecular Pathology
Issue number1
Publication statusPublished - Jan 1985


  • Electron microscopy
  • Primary myelofibrosis
  • Stromal cells

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medicine(all)


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