Strong motion deficits in dyslexia associated with DCDC2 gene alteration

Guido Marco Cicchini, Cecilia Marino, Sara Mascheretti, Daniela Perani, Maria Concetta Morrone

Research output: Contribution to journalArticlepeer-review

Abstract

Dyslexia is a specific impairment in reading that affects 1 in 10 people. Previous studies have failed to isolate a single cause of the disorder, but several candidate genes have been reported. We measured motion perception in two groups of dyslexics, with and without a deletion within the DCDC2 gene, a risk gene for dyslexia. We found impairment for motion particularly strong at high spatial frequencies in the population carrying the deletion. The data suggest that deficits in motion processing occur in a specific genotype, rather than the entire dyslexia population, contributing to the large variability in impairment of motion thresholds in dyslexia reported in the literature.

Original languageEnglish
Pages (from-to)8059-8064
Number of pages6
JournalJournal of Neuroscience
Volume35
Issue number21
DOIs
Publication statusPublished - May 27 2015

Keywords

  • DCDC2
  • Dyslexia
  • Magnocellular
  • Psychophysics
  • Visual motion

ASJC Scopus subject areas

  • Neuroscience(all)

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