Structural Alterations of Subcutaneous Small-Resistance Arteries May Predict Major Cardiovascular Events in Patients With Hypertension

Carolina De Ciuceis, Enzo Porteri, Damiano Rizzoni, Nicola Rizzardi, Silvia Paiardi, Gianluca E M Boari, Marco Miclini, Francesca Zani, Maria Lorenza Muiesan, Francesco Donato, Massimo Salvetti, Maurizio Castellano, Guido A M Tiberio, Stefano M. Giulini, Enrico Agabiti Rosei

Research output: Contribution to journalArticle

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Abstract

Background: Structural alterations in the microcirculation may be considered an important mechanism of organ damage. An increased tunica media to internal lumen ratio of subcutaneous small-resistance arteries (M:L) may predict the development of cardiovascular events in a high-risk population. However, it is not known whether structural alterations of small arteries may also predict major cardiovascular events. Methods: Three hundred three subjects were included in the present study. There were 65 normotensive subjects, 111 patients with essential hypertension (33% of them with diabetes mellitus), 109 patients with secondary forms of hypertension, and 18 normotensive diabetic patients. Small-resistance arteries were dissected from subcutaneous fat biopsies and mounted on an isometric myograph, and the M:L was measured. Subjects were reevaluated after an average follow-up time of 6.9 years to assess the occurrence of cardio-cerebrovascular events. Results: Eleven subjects died of a fatal cardio-cerebrovascular event (FCE), 14 had a major, nonfatal cardiovascular event (stroke or myocardial infarction) (SMI), 23 had a minor cardiovascular event (MCE), and 255 had no cardiovascular event (NCE). A significant difference was observed in M:L and in event-free survival between patients with FCEs + SMIs + MCEs and those with NCE and between patients with FCEs + SMIs and those with NCE. Similar results were obtained by restricting the analysis to patients with essential hypertension. Conclusions: Structural alterations of small-resistance arteries may predict FCE and SMI. The prognostic role of small-resistance artery structure also applies to medium-risk patients with essential hypertension, at least when MCEs are included in the analysis.

Original languageEnglish
Pages (from-to)846-852
Number of pages7
JournalAmerican Journal of Hypertension
Volume20
Issue number8
DOIs
Publication statusPublished - Aug 2007

Fingerprint

Arteries
Hypertension
Myocardial Infarction
Tunica Media
Subcutaneous Fat
Microcirculation
Disease-Free Survival
Diabetes Mellitus
Stroke
Biopsy
Population
Essential Hypertension

Keywords

  • arteries
  • hypertension
  • hypertrophy
  • prognosis
  • remodeling
  • Vessels

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Structural Alterations of Subcutaneous Small-Resistance Arteries May Predict Major Cardiovascular Events in Patients With Hypertension. / De Ciuceis, Carolina; Porteri, Enzo; Rizzoni, Damiano; Rizzardi, Nicola; Paiardi, Silvia; Boari, Gianluca E M; Miclini, Marco; Zani, Francesca; Muiesan, Maria Lorenza; Donato, Francesco; Salvetti, Massimo; Castellano, Maurizio; Tiberio, Guido A M; Giulini, Stefano M.; Agabiti Rosei, Enrico.

In: American Journal of Hypertension, Vol. 20, No. 8, 08.2007, p. 846-852.

Research output: Contribution to journalArticle

De Ciuceis, C, Porteri, E, Rizzoni, D, Rizzardi, N, Paiardi, S, Boari, GEM, Miclini, M, Zani, F, Muiesan, ML, Donato, F, Salvetti, M, Castellano, M, Tiberio, GAM, Giulini, SM & Agabiti Rosei, E 2007, 'Structural Alterations of Subcutaneous Small-Resistance Arteries May Predict Major Cardiovascular Events in Patients With Hypertension', American Journal of Hypertension, vol. 20, no. 8, pp. 846-852. https://doi.org/10.1016/j.amjhyper.2007.03.016
De Ciuceis, Carolina ; Porteri, Enzo ; Rizzoni, Damiano ; Rizzardi, Nicola ; Paiardi, Silvia ; Boari, Gianluca E M ; Miclini, Marco ; Zani, Francesca ; Muiesan, Maria Lorenza ; Donato, Francesco ; Salvetti, Massimo ; Castellano, Maurizio ; Tiberio, Guido A M ; Giulini, Stefano M. ; Agabiti Rosei, Enrico. / Structural Alterations of Subcutaneous Small-Resistance Arteries May Predict Major Cardiovascular Events in Patients With Hypertension. In: American Journal of Hypertension. 2007 ; Vol. 20, No. 8. pp. 846-852.
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abstract = "Background: Structural alterations in the microcirculation may be considered an important mechanism of organ damage. An increased tunica media to internal lumen ratio of subcutaneous small-resistance arteries (M:L) may predict the development of cardiovascular events in a high-risk population. However, it is not known whether structural alterations of small arteries may also predict major cardiovascular events. Methods: Three hundred three subjects were included in the present study. There were 65 normotensive subjects, 111 patients with essential hypertension (33{\%} of them with diabetes mellitus), 109 patients with secondary forms of hypertension, and 18 normotensive diabetic patients. Small-resistance arteries were dissected from subcutaneous fat biopsies and mounted on an isometric myograph, and the M:L was measured. Subjects were reevaluated after an average follow-up time of 6.9 years to assess the occurrence of cardio-cerebrovascular events. Results: Eleven subjects died of a fatal cardio-cerebrovascular event (FCE), 14 had a major, nonfatal cardiovascular event (stroke or myocardial infarction) (SMI), 23 had a minor cardiovascular event (MCE), and 255 had no cardiovascular event (NCE). A significant difference was observed in M:L and in event-free survival between patients with FCEs + SMIs + MCEs and those with NCE and between patients with FCEs + SMIs and those with NCE. Similar results were obtained by restricting the analysis to patients with essential hypertension. Conclusions: Structural alterations of small-resistance arteries may predict FCE and SMI. The prognostic role of small-resistance artery structure also applies to medium-risk patients with essential hypertension, at least when MCEs are included in the analysis.",
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AU - De Ciuceis, Carolina

AU - Porteri, Enzo

AU - Rizzoni, Damiano

AU - Rizzardi, Nicola

AU - Paiardi, Silvia

AU - Boari, Gianluca E M

AU - Miclini, Marco

AU - Zani, Francesca

AU - Muiesan, Maria Lorenza

AU - Donato, Francesco

AU - Salvetti, Massimo

AU - Castellano, Maurizio

AU - Tiberio, Guido A M

AU - Giulini, Stefano M.

AU - Agabiti Rosei, Enrico

PY - 2007/8

Y1 - 2007/8

N2 - Background: Structural alterations in the microcirculation may be considered an important mechanism of organ damage. An increased tunica media to internal lumen ratio of subcutaneous small-resistance arteries (M:L) may predict the development of cardiovascular events in a high-risk population. However, it is not known whether structural alterations of small arteries may also predict major cardiovascular events. Methods: Three hundred three subjects were included in the present study. There were 65 normotensive subjects, 111 patients with essential hypertension (33% of them with diabetes mellitus), 109 patients with secondary forms of hypertension, and 18 normotensive diabetic patients. Small-resistance arteries were dissected from subcutaneous fat biopsies and mounted on an isometric myograph, and the M:L was measured. Subjects were reevaluated after an average follow-up time of 6.9 years to assess the occurrence of cardio-cerebrovascular events. Results: Eleven subjects died of a fatal cardio-cerebrovascular event (FCE), 14 had a major, nonfatal cardiovascular event (stroke or myocardial infarction) (SMI), 23 had a minor cardiovascular event (MCE), and 255 had no cardiovascular event (NCE). A significant difference was observed in M:L and in event-free survival between patients with FCEs + SMIs + MCEs and those with NCE and between patients with FCEs + SMIs and those with NCE. Similar results were obtained by restricting the analysis to patients with essential hypertension. Conclusions: Structural alterations of small-resistance arteries may predict FCE and SMI. The prognostic role of small-resistance artery structure also applies to medium-risk patients with essential hypertension, at least when MCEs are included in the analysis.

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