Structural and functional neuroimaging in PTSD

A neurobiological update

Jeffrey Chee Leong Looi, Marco Pagani, Davide Nardo, Beverley Raphael, Lars Olof Wahlund

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Advances in neuroimaging permit in vivo investigation of the structural and functional neurobiology of post-traumatic stress disorder (PTSD). Recent reviews of structural and functional neuroimaging in PTSD are discussed together with recent studies. The significance of the findings is limited by the disparate groupings of PTSD trauma exposures, making generalization difficult, and this, combined with the heterogeneity inherent in the existing diagnostic criteria, renders the often conflicting data confusing. There has been an emphasis on studies of cortical structures, without adequate consideration of neural circuit models implicating other brain structures. There has been a move towards investigating subsets of symptoms, such as hyperarousal and dissociation, particularly in functional imaging studies. Overall, neuroimaging research in PTSD faces challenges for the future. The key improvements lie in: the definition and classification of trauma exposures, as they are not all equivalent in nature or indeed comparable; the study of restricted phenotypic subsets of symptoms or endophenotypes, such as hyperarousal and dissociation which may have different neural substrates; adequate study designs for power and control of confounders; and more focused research based upon targeted investigation of neural networks putatively involved in the processing and re-experiencing of trauma.

Original languageEnglish
Title of host publicationNeurobiology of Post-Traumatic Stress Disorder
PublisherNova Science Publishers, Inc.
Pages1-20
Number of pages20
ISBN (Print)9781616688516
Publication statusPublished - 2010

Fingerprint

Functional Neuroimaging
Post-Traumatic Stress Disorders
Dissociative Disorders
Neuroimaging
Wounds and Injuries
Endophenotypes
Neurobiology
Research
Brain

ASJC Scopus subject areas

  • Medicine(all)
  • Psychology(all)

Cite this

Looi, J. C. L., Pagani, M., Nardo, D., Raphael, B., & Wahlund, L. O. (2010). Structural and functional neuroimaging in PTSD: A neurobiological update. In Neurobiology of Post-Traumatic Stress Disorder (pp. 1-20). Nova Science Publishers, Inc..

Structural and functional neuroimaging in PTSD : A neurobiological update. / Looi, Jeffrey Chee Leong; Pagani, Marco; Nardo, Davide; Raphael, Beverley; Wahlund, Lars Olof.

Neurobiology of Post-Traumatic Stress Disorder. Nova Science Publishers, Inc., 2010. p. 1-20.

Research output: Chapter in Book/Report/Conference proceedingChapter

Looi, JCL, Pagani, M, Nardo, D, Raphael, B & Wahlund, LO 2010, Structural and functional neuroimaging in PTSD: A neurobiological update. in Neurobiology of Post-Traumatic Stress Disorder. Nova Science Publishers, Inc., pp. 1-20.
Looi JCL, Pagani M, Nardo D, Raphael B, Wahlund LO. Structural and functional neuroimaging in PTSD: A neurobiological update. In Neurobiology of Post-Traumatic Stress Disorder. Nova Science Publishers, Inc. 2010. p. 1-20
Looi, Jeffrey Chee Leong ; Pagani, Marco ; Nardo, Davide ; Raphael, Beverley ; Wahlund, Lars Olof. / Structural and functional neuroimaging in PTSD : A neurobiological update. Neurobiology of Post-Traumatic Stress Disorder. Nova Science Publishers, Inc., 2010. pp. 1-20
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