Structural and functional role of Staphylococcus aureus surface components recognizing adhesive matrix molecules of the host

Pietro Speziale, Giampiero Pietrocola, Simonetta Rindi, Maria Provenzano, Giulio Provenza, Antonella Di Poto, Livia Visai, Carla Renata Arciola

Research output: Contribution to journalArticlepeer-review

Abstract

Staphylococcus aureus is a versatile and harmful human pathogen in both hospital- and community-acquired infections. S. aureus can initiate host infection by adhering to components of the extracellular matrix. Adherence is mediated by a variety of protein adhesins of the microbial surface component recognizing adhesive matrix molecule (MSCRAMM) family. In this article, we describe these MSCRAMMs in terms of structural organization and ligand-binding capacity and discuss their role as a possible target for immunotherapy.

Original languageEnglish
Pages (from-to)1337-1352
Number of pages16
JournalFuture Microbiology
Volume4
Issue number10
DOIs
Publication statusPublished - Dec 2009

Keywords

  • Adhesion
  • Extracellular matrix
  • MSCRAMM
  • Staphylococcus aureus
  • Vaccine

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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