Structural brain connectome and cognitive impairment in Parkinson disease

S Galantucci; F Agosta; Elka Stefanova; S Basaia; MP Van Den Heuvel; T Stojković; E Canu; I Stanković; V Spica; M Copetti; Delia Gagliardi; Vladimir S. Kostić; M Filippi

doi:10.1148/radiol.2016160274

Structural brain connectome and cognitive impairment in Parkinson disease

S Galantucci, F Agosta, Elka Stefanova, S Basaia, MP Van Den Heuvel, T Stojković, E Canu, I Stanković, V Spica, M Copetti, Delia Gagliardi, Vladimir S. Kostić, M Filippi

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To investigate the structural brain connectome in patients with Parkinson disease (PD) and mild cognitive impairment (MCI) and in patients with PD without MCI. Materials and Methods: This prospective study was approved by the local ethics committees, and written informed consent was obtained from all subjects prior to enrollment. The individual structural brain connectome of 170 patients with PD (54 with MCI, 116 without MCI) and 41 healthy control subjects was obtained by using deterministic diffusion-tensor tractography. A network-based statistic was used to assess structural connectivity differences among groups. Results: Patients with PD and MCI had global network alterations when compared with both control subjects and patients with PD without MCI (range, P = .004 to P = .048). Relative to control subjects, patients with PD and MCI had a large basal ganglia and frontoparietal network with decreased fractional anisotropy (FA) in the right hemisphere and a subnetwork with increased mean diffusivity (MD) involving similar regions bilaterally (P

Original language	English
Pages (from-to)	515-525
Number of pages	11
Journal	Radiology
Volume	283
Issue number	2
DOIs	https://doi.org/10.1148/radiol.2016160274
Publication status	Published - 2017

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Structural brain connectome and cognitive impairment in Parkinson disease. / Galantucci, S; Agosta, F; Stefanova, Elka; Basaia, S; Van Den Heuvel, MP; Stojković, T; Canu, E; Stanković, I; Spica, V; Copetti, M; Gagliardi, Delia; Kostić, Vladimir S.; Filippi, M.

In: Radiology, Vol. 283, No. 2, 2017, p. 515-525.

Research output: Contribution to journal › Article › peer-review

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abstract = "Purpose: To investigate the structural brain connectome in patients with Parkinson disease (PD) and mild cognitive impairment (MCI) and in patients with PD without MCI. Materials and Methods: This prospective study was approved by the local ethics committees, and written informed consent was obtained from all subjects prior to enrollment. The individual structural brain connectome of 170 patients with PD (54 with MCI, 116 without MCI) and 41 healthy control subjects was obtained by using deterministic diffusion-tensor tractography. A network-based statistic was used to assess structural connectivity differences among groups. Results: Patients with PD and MCI had global network alterations when compared with both control subjects and patients with PD without MCI (range, P = .004 to P = .048). Relative to control subjects, patients with PD and MCI had a large basal ganglia and frontoparietal network with decreased fractional anisotropy (FA) in the right hemisphere and a subnetwork with increased mean diffusivity (MD) involving similar regions bilaterally (P ",

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AU - Galantucci, S

AU - Agosta, F

AU - Stefanova, Elka

AU - Basaia, S

AU - Van Den Heuvel, MP

AU - Stojković, T

AU - Canu, E

AU - Stanković, I

AU - Spica, V

AU - Copetti, M

AU - Gagliardi, Delia

AU - Kostić, Vladimir S.

AU - Filippi, M

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N2 - Purpose: To investigate the structural brain connectome in patients with Parkinson disease (PD) and mild cognitive impairment (MCI) and in patients with PD without MCI. Materials and Methods: This prospective study was approved by the local ethics committees, and written informed consent was obtained from all subjects prior to enrollment. The individual structural brain connectome of 170 patients with PD (54 with MCI, 116 without MCI) and 41 healthy control subjects was obtained by using deterministic diffusion-tensor tractography. A network-based statistic was used to assess structural connectivity differences among groups. Results: Patients with PD and MCI had global network alterations when compared with both control subjects and patients with PD without MCI (range, P = .004 to P = .048). Relative to control subjects, patients with PD and MCI had a large basal ganglia and frontoparietal network with decreased fractional anisotropy (FA) in the right hemisphere and a subnetwork with increased mean diffusivity (MD) involving similar regions bilaterally (P

AB - Purpose: To investigate the structural brain connectome in patients with Parkinson disease (PD) and mild cognitive impairment (MCI) and in patients with PD without MCI. Materials and Methods: This prospective study was approved by the local ethics committees, and written informed consent was obtained from all subjects prior to enrollment. The individual structural brain connectome of 170 patients with PD (54 with MCI, 116 without MCI) and 41 healthy control subjects was obtained by using deterministic diffusion-tensor tractography. A network-based statistic was used to assess structural connectivity differences among groups. Results: Patients with PD and MCI had global network alterations when compared with both control subjects and patients with PD without MCI (range, P = .004 to P = .048). Relative to control subjects, patients with PD and MCI had a large basal ganglia and frontoparietal network with decreased fractional anisotropy (FA) in the right hemisphere and a subnetwork with increased mean diffusivity (MD) involving similar regions bilaterally (P

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