Structural connectivity in a single case of progressive prosopagnosia: The role of the right inferior longitudinal fasciculus

Dario Grossi, Andrea Soricelli, Marta Ponari, Elena Salvatore, Mario Quarantelli, Anna Prinster, Luigi Trojano

Research output: Contribution to journalArticle


Progressive prosopagnosia (PP) is a clinical syndrome characterized by a progressive and selective inability to recognize and identify faces of familiar people. Here we report a patient (G.S.) with PP, mainly related to a prominent deficit in recognition of familiar faces, without a semantic (cross-modal) impairment. An in-depth evaluation showed that his deficit extended to other classes of objects, both living and non-living. A follow-up neuropsychological assessment did not reveal substantial changes after about 1 year. Structural MRI showed predominant right temporal lobe atrophy.Diffusion tensor imaging was performed to elucidate structural connectivity of the inferior longitudinal fasciculus (ILF) and the inferior fronto-occipital fasciculus (IFOF), the two major tracts that project through the core fusiform region to the anterior temporal and frontal cortices, respectively. Right ILF was markedly reduced in G.S., while left ILF and IFOFs were apparently preserved. These data are in favour of a crucial role of the neural circuit subserved by right ILF in the pathogenesis of PP.

Original languageEnglish
Pages (from-to)111-120
Number of pages10
Publication statusPublished - 2014



  • Diffusion tensor imaging
  • Inferior fronto-occipital fasciculus
  • Inferior longitudinal fasciculus
  • Progressive prosopagnosia

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Arts and Humanities (miscellaneous)
  • Developmental and Educational Psychology
  • Medicine(all)

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