Structural connectome of the human vestibular, pre-motor, and navigation network

I. Indovina, R. Riccelli, L. Passamonti, V. Maffei, G. Bosco, F. Lacquaniti, N. Toschi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The aim of this study is to characterize modules and hubs within the multimodal vestibular system and, particularly, to test the centrality of posterior peri-sylvian regions. Structural connectivity matrices from 50 unrelated healthy right-handed subjects from the Human Connectome Project (HCP) database were analyzed using multishell diffusion-weighted data, probabilistic tractography (constrained spherical-deconvolution informed filtering of tractograms) in combination with subject-specific grey matter parcellations. Network nodes included parcellated regions within the vestibular, pre-motor and navigation system. Module calculation produced two and three modules in the right and left hemisphere, respectively. On the right, regions were grouped into a vestibular and pre-motor module, and into a visual-navigation module. On the left this last module was split into an inferior and superior component. In the thalamus, a region comprising the mediodorsal and anterior complex, and lateral and inferior pulvinar, was included in the ipsilateral navigation module, while the remaining thalamus was clustered with the ipsilateral vestibular pre-motor module. Hubs were located bilaterally in regions encompassing the inferior parietal cortex and the precuneus. This analysis revealed a dorso-lateral path within the multi-modal vestibular system related to vestibular / motor control, and a ventro-medial path related to spatial orientation / navigation. Posterior peri-sylvian regions may represent the main hubs of the whole modular network.

Original languageEnglish
Title of host publication40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages588-591
Number of pages4
Volume2018-July
ISBN (Electronic)9781538636466
DOIs
Publication statusPublished - Oct 26 2018
Event40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 - Honolulu, United States
Duration: Jul 18 2018Jul 21 2018

Conference

Conference40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
CountryUnited States
CityHonolulu
Period7/18/187/21/18

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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    Indovina, I., Riccelli, R., Passamonti, L., Maffei, V., Bosco, G., Lacquaniti, F., & Toschi, N. (2018). Structural connectome of the human vestibular, pre-motor, and navigation network . In 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 (Vol. 2018-July, pp. 588-591). [8512399] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2018.8512399