Structural correlates of implicit learning deficits in subjects with developmental dyslexia

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Several neuroimaging studies in developmental dyslexia (DD) have mainly focused on brain regions subserving phonological processes. However, additional deficits characterize subjects with DD, such as an impairment of visual and rapid stimuli processing and deficits in implicit learning (IL). Little is known about structural abnormalities in brain regions not directly related to phonology and reading processes. The aim of this study was to investigate, using voxel-based morphometry, whether subjects with DD exhibit any structural grey matter (GM) abnormalities in regions that have previously shown abnormal functional magnetic resonance imaging (fMRI) activation during an IL task. Significantly smaller GM volumes were found in the right posterior superior parietal lobule and precuneus and in the right supplementary motor area (SMA) of subjects with DD compared to controls. Moreover, a larger GM volume in parietal cortex was associated with an increase of IL effect in controls but not in subjects with DD. These structural abnormalities are consistent with functional changes and reinforce the hypothesis that an impairment of IL might play a relevant role in learning to read.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages212-221
Number of pages10
Volume1145
DOIs
Publication statusPublished - Dec 2008

Publication series

NameAnnals of the New York Academy of Sciences
Volume1145
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

Dyslexia
Brain
Parietal Lobe
Learning
Neuroimaging
Chemical activation
Processing
Vision Disorders
Motor Cortex
Reading
Magnetic Resonance Imaging
Gray Matter

Keywords

  • Developmental disorders
  • Developmental dyslexia
  • Implicit memory
  • Volumetric MRI
  • Voxel based morphometry

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Menghini, D., Hagberg, G. E., Petrosini, L., Bozzali, M., Macaluso, E., Caltagirone, C., & Vicari, S. (2008). Structural correlates of implicit learning deficits in subjects with developmental dyslexia. In Annals of the New York Academy of Sciences (Vol. 1145, pp. 212-221). (Annals of the New York Academy of Sciences; Vol. 1145). https://doi.org/10.1196/annals.1416.010

Structural correlates of implicit learning deficits in subjects with developmental dyslexia. / Menghini, Deny; Hagberg, Gisela E.; Petrosini, Laura; Bozzali, Marco; Macaluso, Emiliano; Caltagirone, Carlo; Vicari, Stefano.

Annals of the New York Academy of Sciences. Vol. 1145 2008. p. 212-221 (Annals of the New York Academy of Sciences; Vol. 1145).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Menghini, D, Hagberg, GE, Petrosini, L, Bozzali, M, Macaluso, E, Caltagirone, C & Vicari, S 2008, Structural correlates of implicit learning deficits in subjects with developmental dyslexia. in Annals of the New York Academy of Sciences. vol. 1145, Annals of the New York Academy of Sciences, vol. 1145, pp. 212-221. https://doi.org/10.1196/annals.1416.010
Menghini D, Hagberg GE, Petrosini L, Bozzali M, Macaluso E, Caltagirone C et al. Structural correlates of implicit learning deficits in subjects with developmental dyslexia. In Annals of the New York Academy of Sciences. Vol. 1145. 2008. p. 212-221. (Annals of the New York Academy of Sciences). https://doi.org/10.1196/annals.1416.010
Menghini, Deny ; Hagberg, Gisela E. ; Petrosini, Laura ; Bozzali, Marco ; Macaluso, Emiliano ; Caltagirone, Carlo ; Vicari, Stefano. / Structural correlates of implicit learning deficits in subjects with developmental dyslexia. Annals of the New York Academy of Sciences. Vol. 1145 2008. pp. 212-221 (Annals of the New York Academy of Sciences).
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