Abstract
Several neuroimaging studies in developmental dyslexia (DD) have mainly focused on brain regions subserving phonological processes. However, additional deficits characterize subjects with DD, such as an impairment of visual and rapid stimuli processing and deficits in implicit learning (IL). Little is known about structural abnormalities in brain regions not directly related to phonology and reading processes. The aim of this study was to investigate, using voxel-based morphometry, whether subjects with DD exhibit any structural grey matter (GM) abnormalities in regions that have previously shown abnormal functional magnetic resonance imaging (fMRI) activation during an IL task. Significantly smaller GM volumes were found in the right posterior superior parietal lobule and precuneus and in the right supplementary motor area (SMA) of subjects with DD compared to controls. Moreover, a larger GM volume in parietal cortex was associated with an increase of IL effect in controls but not in subjects with DD. These structural abnormalities are consistent with functional changes and reinforce the hypothesis that an impairment of IL might play a relevant role in learning to read.
| Original language | English |
|---|---|
| Title of host publication | Annals of the New York Academy of Sciences |
| Pages | 212-221 |
| Number of pages | 10 |
| Volume | 1145 |
| DOIs | |
| Publication status | Published - Dec 2008 |
Publication series
| Name | Annals of the New York Academy of Sciences |
|---|---|
| Volume | 1145 |
| ISSN (Print) | 00778923 |
| ISSN (Electronic) | 17496632 |
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Keywords
- Developmental disorders
- Developmental dyslexia
- Implicit memory
- Volumetric MRI
- Voxel based morphometry
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Structural correlates of implicit learning deficits in subjects with developmental dyslexia. / Menghini, Deny; Hagberg, Gisela E.; Petrosini, Laura; Bozzali, Marco; Macaluso, Emiliano; Caltagirone, Carlo; Vicari, Stefano.
Annals of the New York Academy of Sciences. Vol. 1145 2008. p. 212-221 (Annals of the New York Academy of Sciences; Vol. 1145).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Structural correlates of implicit learning deficits in subjects with developmental dyslexia
AU - Menghini, Deny
AU - Hagberg, Gisela E.
AU - Petrosini, Laura
AU - Bozzali, Marco
AU - Macaluso, Emiliano
AU - Caltagirone, Carlo
AU - Vicari, Stefano
PY - 2008/12
Y1 - 2008/12
N2 - Several neuroimaging studies in developmental dyslexia (DD) have mainly focused on brain regions subserving phonological processes. However, additional deficits characterize subjects with DD, such as an impairment of visual and rapid stimuli processing and deficits in implicit learning (IL). Little is known about structural abnormalities in brain regions not directly related to phonology and reading processes. The aim of this study was to investigate, using voxel-based morphometry, whether subjects with DD exhibit any structural grey matter (GM) abnormalities in regions that have previously shown abnormal functional magnetic resonance imaging (fMRI) activation during an IL task. Significantly smaller GM volumes were found in the right posterior superior parietal lobule and precuneus and in the right supplementary motor area (SMA) of subjects with DD compared to controls. Moreover, a larger GM volume in parietal cortex was associated with an increase of IL effect in controls but not in subjects with DD. These structural abnormalities are consistent with functional changes and reinforce the hypothesis that an impairment of IL might play a relevant role in learning to read.
AB - Several neuroimaging studies in developmental dyslexia (DD) have mainly focused on brain regions subserving phonological processes. However, additional deficits characterize subjects with DD, such as an impairment of visual and rapid stimuli processing and deficits in implicit learning (IL). Little is known about structural abnormalities in brain regions not directly related to phonology and reading processes. The aim of this study was to investigate, using voxel-based morphometry, whether subjects with DD exhibit any structural grey matter (GM) abnormalities in regions that have previously shown abnormal functional magnetic resonance imaging (fMRI) activation during an IL task. Significantly smaller GM volumes were found in the right posterior superior parietal lobule and precuneus and in the right supplementary motor area (SMA) of subjects with DD compared to controls. Moreover, a larger GM volume in parietal cortex was associated with an increase of IL effect in controls but not in subjects with DD. These structural abnormalities are consistent with functional changes and reinforce the hypothesis that an impairment of IL might play a relevant role in learning to read.
KW - Developmental disorders
KW - Developmental dyslexia
KW - Implicit memory
KW - Volumetric MRI
KW - Voxel based morphometry
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UR - http://www.scopus.com/inward/citedby.url?scp=57649108742&partnerID=8YFLogxK
U2 - 10.1196/annals.1416.010
DO - 10.1196/annals.1416.010
M3 - Conference contribution
C2 - 19076399
AN - SCOPUS:57649108742
SN - 9781573317023
VL - 1145
T3 - Annals of the New York Academy of Sciences
SP - 212
EP - 221
BT - Annals of the New York Academy of Sciences
ER -