Structural organization of multiple alphoid subsets coexisting on human chromosomes 1, 4, 5, 7, 9, 15, 18, and 19

Palma Finelli, Rachele Antonacci, Rosalia Marzella, Angelo Lonoce, Nicoletta Archidiacono, Mariano Rocchi

Research output: Contribution to journalArticle

Abstract

FISH experiments on metaphase chromosomes, interphase nuclei, and extended chromatin were performed to investigate the structural organization of alphoid subsets coexisting on human chromosomes 1, 4, 5, 7, 9, 15, 18, and 19. Results indicate that multiple subsets present on chromosomes 5, 7, 15, 18, and 19 are organized in structurally distinct and contiguous domains, while those on chromosomes 4 and 9 give perfectly overlapping signals. Chromosome 1 shows a peculiar organization: probe pAL1, specific for this chromosome, detects two distinct domains separated by the subset identified by probe pZ5.1. The order along the chromosome of alphoid subsets lying on chromosomes 5, 7, 15, 18, and 19, organized in distinct blocks, has also been established. The relationship between the structural organization of these alphoid sequences and their evolutionary history in great apes is discussed.

Original languageEnglish
Pages (from-to)325-330
Number of pages6
JournalGenomics
Volume38
Issue number3
DOIs
Publication statusPublished - Dec 15 1996

ASJC Scopus subject areas

  • Genetics

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