Structural synaptic remodeling in the perirhinal cortex of adult and old rats following object-recognition visual training

D. Platano, C. Bertoni-Freddari, P. Fattoretti, B. Giorgetti, Y. Grossi, M. Balietti, T. Casoli, G. Di Stefano, G. Aicardi

Research output: Contribution to journalArticle

Abstract

The ultrastructural features of layer II synapses in the perirhinal cortex of adult (4- to 6-month-old) and old (25- to 27-month-old) rats exposed to a six-session object recognition visual training were investigated by morphometric methods. The comparative analysis showed a higher synaptic numeric density, a lower synaptic average area, and a lower percentage of mega-synapses (S > 0.5 μm2) in old trained rats versus controls, and a higher percentage of small (S <0.15 μm2) junctions in adult trained rats versus controls. The more marked synaptic remodeling underlying memory consolidation in the perirhinal cortex of old rats might reflect a pre-existing lower dynamic status.

Original languageEnglish
Pages (from-to)102-106
Number of pages5
JournalRejuvenation Research
Volume9
Issue number1
DOIs
Publication statusPublished - Mar 2006

ASJC Scopus subject areas

  • Ageing

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