Structurally related glucosylated liposomes: Correlation of physicochemical and biological features

Alessandro Mauceri, Luisa Giansanti, Giuseppina Bozzuto, Maria Condello, Agnese Molinari, Luciano Galantini, Antonella Piozzi, Giovanna Mancini

Research output: Contribution to journalArticlepeer-review

Abstract

Liposomes functionalized on their surface with carbohydrates (glycoliposomes) represent an optimal approach for targeting of drugs to diseased tissues in vivo, thanks to biocompatibility, low toxicity and easy manufacturing of these lipid nanoparticles. Here we report on the study of liposomes including a novel glycosylated amphiphile and on the comparison of their features with those of glycosylated analogues described previously. Further, the capability of the different glucosylated formulations to interact with three breast cancer cell lines was investigated. Our results show that the hydrophobic portion of the lipid bilayer strongly influences both the properties and the internalization of glycosylated liposomes.

Original languageEnglish
Pages (from-to)1468-1475
Number of pages8
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1861
Issue number8
DOIs
Publication statusPublished - Aug 1 2019

Keywords

  • Breast Neoplasms/metabolism
  • Cell Line, Tumor
  • Female
  • Flow Cytometry
  • Glucose/chemistry
  • Glycolipids/chemistry
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Liposomes
  • Microscopy, Confocal
  • Surface Properties
  • Surface-Active Agents/chemistry

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