Abstract
Using the potent cyclic peptide T analog -thr-Thr-Asn-Tyr-Thr-Asp- as parent compound, a series of analogues were synthesized and their potencies in a monocyte chemotaxis assay were compared with those of correspondingly modified linear peptides. Structure-activity relationships observed with cyclic compounds did not always parallel those determined with linear analogues. -Thr-Hse-Asn-Tyr-Thr-Asp- showed the highest affinity to CD4 receptor of monocytes of any peptide thus far studied. It also proved to be highly resistant to degradation by plasma or brain enzymes.
| Original language | English |
|---|---|
| Pages (from-to) | 447-454 |
| Number of pages | 8 |
| Journal | International Journal of Peptide and Protein Research |
| Volume | 41 |
| Issue number | 5 |
| Publication status | Published - 1993 |
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Keywords
- Biodegradation
- Chemotactic activity
- Homoserine into synthetic peptides
- Peptide T cyclic analogues
ASJC Scopus subject areas
- Biochemistry
Cite this
Structure-activity relationships of cyclic and linear peptide T analogues. / Marastoni, M.; Salvadori, S.; Balboni, G.; Scaranari, V.; Spisani, S.; Reali, E.; Traniello, S.; Tomatis, R.
In: International Journal of Peptide and Protein Research, Vol. 41, No. 5, 1993, p. 447-454.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Structure-activity relationships of cyclic and linear peptide T analogues
AU - Marastoni, M.
AU - Salvadori, S.
AU - Balboni, G.
AU - Scaranari, V.
AU - Spisani, S.
AU - Reali, E.
AU - Traniello, S.
AU - Tomatis, R.
PY - 1993
Y1 - 1993
N2 - Using the potent cyclic peptide T analog -thr-Thr-Asn-Tyr-Thr-Asp- as parent compound, a series of analogues were synthesized and their potencies in a monocyte chemotaxis assay were compared with those of correspondingly modified linear peptides. Structure-activity relationships observed with cyclic compounds did not always parallel those determined with linear analogues. -Thr-Hse-Asn-Tyr-Thr-Asp- showed the highest affinity to CD4 receptor of monocytes of any peptide thus far studied. It also proved to be highly resistant to degradation by plasma or brain enzymes.
AB - Using the potent cyclic peptide T analog -thr-Thr-Asn-Tyr-Thr-Asp- as parent compound, a series of analogues were synthesized and their potencies in a monocyte chemotaxis assay were compared with those of correspondingly modified linear peptides. Structure-activity relationships observed with cyclic compounds did not always parallel those determined with linear analogues. -Thr-Hse-Asn-Tyr-Thr-Asp- showed the highest affinity to CD4 receptor of monocytes of any peptide thus far studied. It also proved to be highly resistant to degradation by plasma or brain enzymes.
KW - Biodegradation
KW - Chemotactic activity
KW - Homoserine into synthetic peptides
KW - Peptide T cyclic analogues
UR - http://www.scopus.com/inward/record.url?scp=0027285047&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027285047&partnerID=8YFLogxK
M3 - Article
C2 - 8320038
AN - SCOPUS:0027285047
VL - 41
SP - 447
EP - 454
JO - International Journal of Peptide and Protein Research
JF - International Journal of Peptide and Protein Research
SN - 0367-8377
IS - 5
ER -