Structure-activity relationships of cyclic and linear peptide T analogues

M. Marastoni; S. Salvadori; G. Balboni; V. Scaranari; S. Spisani; E. Reali; S. Traniello; R. Tomatis

Structure-activity relationships of cyclic and linear peptide T analogues

M. Marastoni, S. Salvadori, G. Balboni, V. Scaranari, S. Spisani, E. Reali, S. Traniello, R. Tomatis

IRCCS Istituto Ortopedico Galeazzi

Research output: Contribution to journal › Article › peer-review

Abstract

Using the potent cyclic peptide T analog -thr-Thr-Asn-Tyr-Thr-Asp- as parent compound, a series of analogues were synthesized and their potencies in a monocyte chemotaxis assay were compared with those of correspondingly modified linear peptides. Structure-activity relationships observed with cyclic compounds did not always parallel those determined with linear analogues. -Thr-Hse-Asn-Tyr-Thr-Asp- showed the highest affinity to CD4 receptor of monocytes of any peptide thus far studied. It also proved to be highly resistant to degradation by plasma or brain enzymes.

Original language	English
Pages (from-to)	447-454
Number of pages	8
Journal	International Journal of Peptide and Protein Research
Volume	41
Issue number	5
Publication status	Published - 1993

Keywords

Biodegradation
Chemotactic activity
Homoserine into synthetic peptides
Peptide T cyclic analogues

ASJC Scopus subject areas

Biochemistry

Cite this

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abstract = "Using the potent cyclic peptide T analog -thr-Thr-Asn-Tyr-Thr-Asp- as parent compound, a series of analogues were synthesized and their potencies in a monocyte chemotaxis assay were compared with those of correspondingly modified linear peptides. Structure-activity relationships observed with cyclic compounds did not always parallel those determined with linear analogues. -Thr-Hse-Asn-Tyr-Thr-Asp- showed the highest affinity to CD4 receptor of monocytes of any peptide thus far studied. It also proved to be highly resistant to degradation by plasma or brain enzymes.",

keywords = "Biodegradation, Chemotactic activity, Homoserine into synthetic peptides, Peptide T cyclic analogues",

author = "M. Marastoni and S. Salvadori and G. Balboni and V. Scaranari and S. Spisani and E. Reali and S. Traniello and R. Tomatis",

year = "1993",

language = "English",

volume = "41",

pages = "447--454",

journal = "International journal of protein research",

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T1 - Structure-activity relationships of cyclic and linear peptide T analogues

AU - Marastoni, M.

AU - Salvadori, S.

AU - Balboni, G.

AU - Scaranari, V.

AU - Spisani, S.

AU - Reali, E.

AU - Traniello, S.

AU - Tomatis, R.

PY - 1993

Y1 - 1993

N2 - Using the potent cyclic peptide T analog -thr-Thr-Asn-Tyr-Thr-Asp- as parent compound, a series of analogues were synthesized and their potencies in a monocyte chemotaxis assay were compared with those of correspondingly modified linear peptides. Structure-activity relationships observed with cyclic compounds did not always parallel those determined with linear analogues. -Thr-Hse-Asn-Tyr-Thr-Asp- showed the highest affinity to CD4 receptor of monocytes of any peptide thus far studied. It also proved to be highly resistant to degradation by plasma or brain enzymes.

AB - Using the potent cyclic peptide T analog -thr-Thr-Asn-Tyr-Thr-Asp- as parent compound, a series of analogues were synthesized and their potencies in a monocyte chemotaxis assay were compared with those of correspondingly modified linear peptides. Structure-activity relationships observed with cyclic compounds did not always parallel those determined with linear analogues. -Thr-Hse-Asn-Tyr-Thr-Asp- showed the highest affinity to CD4 receptor of monocytes of any peptide thus far studied. It also proved to be highly resistant to degradation by plasma or brain enzymes.

KW - Biodegradation

KW - Chemotactic activity

KW - Homoserine into synthetic peptides

KW - Peptide T cyclic analogues

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Structure-activity relationships of cyclic and linear peptide T analogues

Abstract

Keywords

ASJC Scopus subject areas

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