Structure and expression of oncogenes in surgical specimens of human breast carcinomas

I. Biunno, M. R. Pozzi, M. A. Pierotti, S. Pilotti, G. Cattoretti, G. Della Porta

Research output: Contribution to journalArticlepeer-review


We have performed an analysis of ras, c-myc, c-myb, c-erbB1 and c-erbB2 oncogenes in 100 surgical samples of human breast carcinomas. No point mutations have been detected at the 12th codon of c-Ha-ras and c-Ki-ras in 40 and 65 breast cancer DNAs, respectively. One out of 65 samples showed a 50-fold amplication of c-Ha-ras that, however, was not overexpressed. Alterations in the structure of c-myc, c-myb c-erbB1 and c-erbB2 oncogenes were sporadically observed. In 20 tumour samples, the study of expression of a series of oncogenes revealed that c-Ha-ras was the predominantly transcribed gene among the ras gene family whereas c-fos appeared the most constantly and significantly expressed nuclear oncogene.

Original languageEnglish
Pages (from-to)464-468
Number of pages5
JournalBritish Journal of Cancer
Issue number5
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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