(Chemical Equation Presented) We have optimized previously discovered benzoic acids 1, which are active as inhibitors of PTP1B and LMW-PTP, two protein tyrosine phosphatases that have emerged as attractive targets for the development of novel therapeutic agents for the treatment of diabetes, obesity, and cancer. Our efforts led to the identification of new and more potent analogues with appreciable selectivity toward human PTP1B and the IF1 isoform of human LMW-PTP.
- Benzoic acids
- Drug design
- Protein tyrosine phosphatases
ASJC Scopus subject areas
- Molecular Medicine
- Organic Chemistry
- Pharmacology, Toxicology and Pharmaceutics(all)